Category: 5. Biology

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  • Neocarzilin A induces apoptosis and mitochondrial disturbance by targeting reticulon 4-mediated endoplasmic reticulum stress

    Neocarzilin A induces apoptosis and mitochondrial disturbance by targeting reticulon 4-mediated endoplasmic reticulum stress

    Cell lines and culture

    HeLa cells were obtained from DSMZ (Braunschweig, Germany) and were cultured in Dulbecco’s Modified Eagle’s Medium high glucose (DMEM) (PAN Biotech, Aidenbach, Germany) supplemented with 10% (v/v) fetal calf serum (PAN…

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  • Making sense of the polygenicity of complex traits

    In the early twentieth century, scientists faced a puzzle: if hereditary material is transmitted in discrete units, how can traits such as height show continuous or quantitative variation? This puzzle was largely resolved by R. A. Fisher in 1918,…

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  • Advancing therapeutics in small-cell lung cancer

    Advancing therapeutics in small-cell lung cancer

  • International Agency for Research on Cancer. Absolute Numbers, Mortality, Both Sexes, in 2022 gco.iarc.fr/today/en/dataviz/pie?mode=cancer&group_populations=1&types=1 (2022).

  • Ganti, A. K., Klein, A. B., Cotarla, I., Seal, B. & Chou, E. Update of…

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  • A chromosome-level genome assembly of the Bullacta exarata (Cephalaspidea: Haminoeidae)

    A chromosome-level genome assembly of the Bullacta exarata (Cephalaspidea: Haminoeidae)

  • Malaquias, M. A. E. Systematics, phylogeny, and natural history of Bullacta exarata (Philippi, 1849): an endemic cephalaspidean gastropod from the China Sea. J. Nat. Hist. 44, 2015–2029 (2010).

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  • Automated model refinement using perturbation-observation pairs

    Automated model refinement using perturbation-observation pairs

    Methodological details of boolmore

    Mutating functions such that edge signs are preserved

    The interactions and regulatory relationships in biological networks are locally monotonic in the vast majority of cases. This means a…

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  • Retinal astrocytoma as a presenting feature of tuberous sclerosis: a photo essay

    Retinal astrocytoma as a presenting feature of tuberous sclerosis: a photo essay

    Retinal astrocytoma as a presenting feature of tuberous sclerosis: a photo essay

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  • Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome

    Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome

    Clinical, genetic, and image characteristics in individuals with FOXG1 syndrome

    We collected clinical, brain MRI, and genetic data from 14 FOXG1 syndrome cases, with 5 from our hospital and 9 from the literature [17, 18, 39, 40]. All cases carried…

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