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Category: 5. Biology

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  • Structural analyses define the molecular basis of clusterin chaperone function

    Structural analyses define the molecular basis of clusterin chaperone function

    Plasmids

    The pB-T-PAF-Clu plasmid used for WT Clu expression and purification was constructed by amplifying the coding region of pB-T-PAF-CluStrep22 by PCR. The PCR product was then digested with NheI and NotI and subcloned into the pB-T-PAF…

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  • Somatic hypermutation at a multiway chromatin hub

    Somatic hypermutation (SHM) is crucial for antibody maturation, and new antibody isotypes are generated by class switch recombination at the immunoglobulin heavy-chain (IGH) locus. This is thought to require a specific topology induced by…

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  • Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain

    Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain

    Animals, brain slice preparation, and brain homogenization

    Four-month-old male Wistar rats were purchased in Rappolovo laboratory animal nursery (Saint-Petersburg, Russia). Domestic chickens (Gallus gallus domesticus) of the Russian White breed,…

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  • Correction: Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair

  • Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Dr., Gaithersburg, MD, 20899, USA

    Jennifer H. McDaniel, Vaidehi Patel, Nathan D. Olson, Hua-Jun He, Zhiyong He, Kenneth D. Cole, Alexander A….

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  • Nanoscale spatiotemporal cluster analysis of expressed and endogenous proteins

    Nanoscale spatiotemporal cluster analysis of expressed and endogenous proteins

  • Gormal, R. S. & Meunier, F. A. Nanoscale organization of the pre-synapse: tracking the neurotransmitter release machinery. Curr. Opin. Neurobiol. 75, 102576 (2022).

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  • Retraction Note: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

    Retraction Note: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

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  • Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma

    Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma

    Identification of CAF marker genes in the melanoma

    To identify melanoma cell types, we obtained public scRNA sequencing data from the GEO dataset GSE115978. We obtained 3,630 high-quality single-cell data after quality control processing and then…

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  • Whole-genome doubling in ovarian cancer

    Reporting in Nature, McPherson et al. provide insights into why whole-genome doubling (WGD) is frequently observed in ovarian cancer. The team used single-cell DNA sequencing to analyze WGD events in 70 multi-site samples from a cohort of 41…

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