Category: 5. Biology

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  • Reversible proliferative arrest induced by rapid depletion of RNase MRP

    Reversible proliferative arrest induced by rapid depletion of RNase MRP

  • Zhu, J. & Thompson, C. B. Metabolic regulation of cell growth and proliferation. Nat. Rev. Mol. Cell Biol. 20, 436–450 (2019).

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  • Targeting de novo purine biosynthesis for tuberculosis treatment

    Targeting de novo purine biosynthesis for tuberculosis treatment

    Ethics and inclusion statement

    This research represents a collaborative effort between multiple research groups based in Belgium, the UK, South Africa, the USA, Canada, France and Spain. Authorship was determined solely based on substantial…

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  • Investigating the molecular ‘scars’ of PTSD in the human brain

    Investigating the molecular ‘scars’ of PTSD in the human brain

    Investigating the molecular ‘scars’ of PTSD in the human brain

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  • Morphodynamics of human early brain organoid development

    Morphodynamics of human early brain organoid development

    Experimental methods

    Stem cell and organoid culture

    We used the following induced pluripotent stem (iPS) cell line for all experiments (also see Supplementary Methods Table 1): histone2B–mEGFP that uniformly labels nuclei (cell line ID:…

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  • A ‘killswitch’ peptide solidifies protein droplets in living cells

    A ‘killswitch’ peptide solidifies protein droplets in living cells

    • RESEARCH BRIEFINGS

    Human cells contain dozens of different types of…

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  • Correction: Four dimensions of individualization in brain stimulation for psychiatric disorders: context, target, dose, and timing

  • Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA

    Ghazaleh Soleimani, Kelvin O. Lim & Hamed Ekhtiari

  • Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

    Ghazaleh…

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  • The complexity and commonness of the two-process model of sleep regulation from a mathematical perspective

    The complexity and commonness of the two-process model of sleep regulation from a mathematical perspective

    Neuronal mechanisms underpinning the two-process model

    Since the 1980’s we have learned much about the brain structures involved in sleep regulation. Saper, Scammell & Lu22 conceptualised sleep-wake regulation as the result of the mutual…

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  • Fifty years of limnological data on Lake Stechlin, a temperate clearwater lake

    Fifty years of limnological data on Lake Stechlin, a temperate clearwater lake

  • Dudgeon, D. et al. Freshwater biodiversity: importance, threats, status and conservation challenges. Biol. Rev. 81, 163–182 (2006).

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  • Reid, A. J. et al. Emerging…

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  • The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment

    The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment

    Patient cohort and quality control

    After quality control, 72 samples were subject to at least one of the assays across the study. Post-QC 69, 62 and 51 tumour cores were analysed for the immuno-oncology proteome atlas (IPA), whole transcriptome…

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