Ethical approval
This study was carried out in accordance with regulations by the institutional animal care and use committee of the Nagoya Institute of Technology (approval number: 2021009). All methods are reported in accordance with the ARRIVE…
Category: 5. Biology
-
Complete computational design of high-efficiency Kemp elimination enzymes
Röthlisberger, D. et al. Kemp elimination catalysts by computational enzyme design. Nature 453, 190–195 (2008).
Google Scholar
Siegel, J. B. et al. Computational design…
Continue Reading
-
Innate immune responses to pathogens at the maternal–fetal interface
Devaraju, M. et al. Beyond TORCH: a narrative review of the impact of antenatal and perinatal infections on the risk of disability. Neurosci. Biobehav. Rev. 153, 105390 (2023).
…
Continue Reading
-
Unsupervised pretraining in biological neural networks
All experimental procedures were conducted according to the Institutional Animal Care and Use Committee (IACUC), and received ethical approval from the IACUC board at the HHMI Janelia Research Campus.
Experimental methods
Animals
We performed 89…
Continue Reading
-
Generalist medical foundation model improves prostate cancer segmentation from multimodal MRI images
Foundation model for image segmentation
A large number of foundation models have been published for a variety of computer vision tasks, but most of them rely on the interaction of images and texts20,22,24,25,26. We selected Segment Anything Model…
Continue Reading
-
Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities
Parkinson’s disease (PD) is the second-most predominant progressive neurodegenerative disorder in the world. Considering a booming ageing population in many developed nations, the proportion of people afflicted with this crippling disorder is…
Continue Reading
-
Blocking the functional domain of cancer cell surface TIP1 upregulates Midkine via the β-catenin/Wnt signaling pathway
Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.
Google Scholar
Chan BA, Hughes BG. Targeted therapy for non-small cell lung cancer: current…
Continue Reading
-
Phenotypic plasticity co-varies with elevational range in two avian species of elevational migrants in the Himalayas
Sampling sites
We captured the small-scale elevational migrant (T. indicus, n = 21) and the large-scale elevational migrant (T. chrysaeus, n = 23) from wild, sympatric populations in Hailuogou Valley, Sichuan, China (29.58° N, longitude,…
Continue Reading
-
Peripheral infection wires T cells in the brain
Mix, M. R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-025-02174-y (2025).
Google Scholar
Smolders, J. et al. Nat. Commun. 9, 4593 (2018).
Continue Reading
