Critical Path Institute’s® (C-Path) Translational Therapeutics Accelerator (TRxA) proudly announced today a $250,000 grant award aimed at developing a novel treatment for type 1 diabetes (T1D). Kyle Apley, Ph.D., Cory Berkland,…
Category: 5. Biology
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Utah State biologist investigates chromosomal changes driving evolution
How do living things evolve? What is the myriad of processes by which generic variations in a population affect organisms’ survival and allow reproduction in an ever-changing environment? Why do these processes often crawl over…
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Fruit fly study reveals how muscle cells sculpt organs
A new study from scientists at the University of North Carolina at Chapel Hill reveals that the cells shaping our organs may be far more mobile and coordinated than once believed.
Using fruit flies as a model, researchers…
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Clonal hematopoiesis as the intersection between genetics and resilience in Alzheimer’s disease
Alzheimer’s Association. 2023 Alzheimer’s disease facts and figures. Alzheimer’s Dement. 19, 1598–1695, https://doi.org/10.1002/alz.13016 (2023).
Arboleda-Velasquez, J. F. et al. Resistance to autosomal dominant Alzheimer’s disease in an…
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Author Correction: A randomized controlled trial of a digital lifestyle intervention involving postoperative patients with colorectal cancer
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking
Cell culture
A549 cells (Lung Carcinoma, American Type Culture Collection, ATCC CRL-185) were cultured in F-12K (Kaighn’s) medium (Gibco, Thermo Fisher Scientific, #21127022) supplemented with 10% fetal bovine serum (FBS) (Thermo Fisher…
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Community science helps digitize 78 years of fish and habitat data for thousands of lakes in Michigan, USA
Tranvik, L. J. et al. Lakes and reservoirs as regulators of carbon cycling and climate. Limnology and Oceanography 54, 2298–2314 (2009).
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Peters N. E. et al….
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Organelle conversations drive ferroptosis | Nature Cell Biology
Sassano, M. L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-025-01668-z (2025).
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Doll, S. et al. Nat. Chem. Biol. 13, 91–98 (2017).
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Butyrate improves abnormal sleep architecture in a Parkinson’s disease mouse model via BDNF/TrkB signaling
Animal acquisition
Young C57BL/6 J male mice, aged 7–8 weeks and weighing 22–25 g, were purchased from GemPharmatech Co., Ltd. (Jiangsu, China). A total of 168 mice were used in the experiment. All the mice were housed at 20–26 °C,…
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Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8)
In the present study, we attempted to encapsulate an RNP complex, a higher-order structure, in a MITO-Porter. We have previously encapsulated other macromolecules, such as nucleic acids and proteins, but this was our first attempt at…
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