Correction: Emerging roles of cohesin-STAG2 in cancer
Category: 5. Biology
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Correction: Emerging roles of cohesin-STAG2 in cancer
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A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
Dataset description and preprocessing
snRNA-seq IPF dataset
In this study, we used snRNA-seq technology to profile the IPF disease progression. For the advantages of using snRNA-seq over scRNA-seq in this study, see Supplementary Note 4. The…
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Deep learning-designed dynamics | Nature Chemical Biology
Deep learning-based approaches have advanced the de novo design of static proteins and enabled robust prediction of structure from sequence. However, computational approaches for designing specific protein structures with user-defined features…
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Evaluating gene expression and biomarkers for mastitis resistance in Barki sheep
To the best of our knowledge, no study has directly connected genetic variations, serum biochemical, antioxidant, and inflammatory markers (APPs) to the risk of mastitis in Barki sheep. Therefore, the aim of this study was to evaluate…
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Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Computational methods for cyclic peptide binder design
Macrocyclic peptide monomers and binders were designed with RFpeptides using a three-stage pipeline: backbone generation using RFdiffusion with the cyclic offset applied to the peptide chains,…
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Noncoded cancer antigens | Nature Chemical Biology
Aberrant translation in cancer cells can lead to the expression of peptides from genetic sequences outside of annotated open reading frames, such as 5′ and 3′ untranslated regions (UTRs), long noncoding RNAs, and alternative reading frames….
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Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis
Harborg, S. et al. New Horizons: Epidemiology of obesity, diabetes mellitus, and cancer prognosis. J. Clin. Endocrinol. Metab. 109, 924–935. https://doi.org/10.1210/clinem/dgad450 (2024).
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Age-related changes in the proteome and mitochondrial metabolism of rabbit adipose-derived stromal/stem cells
Anderson, G. F. & Hussey, P. S. Population aging: A comparison among industrialized countries. Health Aff. Proj. Hope 19, 191–203 (2000).
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Wiener, J. M. & Tilly, J….
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Scientists Debunk Long-Held “Darwin’s Paradox” Myth About Coral Reefs
Most coral reefs do not thrive in nutrient-poor “marine deserts” as once believed, but instead flourish in nutrient-rich waters. Coral reefs are among the most frequently featured subjects in nature documentaries, admired worldwide for their…
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