Sample preparation and sequencing
Leaves from 4-week old S. tuberosum cv. Désirée plants were collected and flash-frozen. High molecular weight genomic DNA (HMW gDNA) used for PacBio HiFi, Illumina and Oxford Nanopore Technologies (ONT)…
Category: 5. Biology
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Phase in phase | Nature Chemical Biology
TDP-43 is a nuclear protein that can bind RNA and have an important role in regulating various RNA-related biological processes. Under disease conditions, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, TDP-43…
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Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
Quantitative models of resistance evolution
We developed mathematical models of resistance evolution that described the response of a population of cancer cells to periodic drug treatment. We aimed to infer the dynamics solely using the change in…
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Imaging lung lymphatics in action in metastatic cancer
Cancer cells invade lymphatic vessels to colonize lymph nodes and evade immune responses. Therefore, the idea of developing treatments to prevent cancers from exploiting the lymphatic system is attractive. However, any therapeutics targeting the…
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Potassium and methionine mitigate the alternate bearing of Balady mandarin via reducing gibberellins and increasing salicylic acid and auxins
FAO. FAO Citrus Fruit Statistical Compendium. ; FAO: Rome, Italy, 2021. (2020).
Suri, S., Singh, A. & Nema, P. K. Current applications of Citrus fruit processing waste: A scientific outlook. Appl. Food Res. 2, 100050 (2022).
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Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells
Ethics statement
This research complies with all relevant ethics regulations at the University of Oxford. Animal procedures were completed under the authority of the UK Home Office project and personal licences granted under the Animals…
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High-throughput method for decoding the protein sequence determinants of condensates
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Kappel, K. et al. Characterizing protein sequence determinants of nuclear condensates…
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