In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious. Now, Scripps Research scientists have developed a synthetic biology platform…
Category: 5. Biology
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RNA sequencing reveals molecular drivers for better regenerative therapies
Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation…
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CRISPR screening uncovers microproteins involved in fat storage
The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide. This prevalent condition is also linked to other metabolic disorders, including type 2 diabetes, cardiovascular diseases,…
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Researchers uncover dozens of traits driven by maternal versus paternal genes
By tracing maternal and paternal inheritance without parental DNA, scientists have mapped dozens of parent-specific genetic effects, uncovering how the same variant can drive or protect against disease depending on which parent it…
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Whole-genome doubling in ovarian cancer
Reporting in Nature, McPherson et al. provide insights into why whole-genome doubling (WGD) is frequently observed in ovarian cancer. The team used single-cell DNA sequencing to analyze WGD events in 70 multi-site samples from a cohort of 41…
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Cancer stem cells and Lon-noncRNA promotes invasion, metastasis and tumor growth in breast cancer through regulation of signaling pathway
Study subjects
The study cohort comprised 30 patients diagnosed with metastatic breast cancer (MBC) who were evaluated and treated at the Baheya Foundation for Early Detection and Treatment of Breast Cancer, Egypt. All cases were confirmed through…
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Rules of partitioning | Nature Reviews Cancer
Membraneless compartments within cells that concentrate specific molecules, known as biomolecular condensates, are increasingly being recognized in controlling cancer-related processes, such as oncogenic transcription. Lyons et al. set out to…
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Development of a versatile chassis for the efficient production of diverse type II polyketides
Selection of the optimal host for heterologous expression of T2PKs
Through a comparative analysis of the functional characteristics across distinct organism hosts, we prioritized Streptomyces hosts as the initial focus for chassis development due…
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SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors
Kyle, R. A. et al. Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N. Engl. J. Med. 356, 2582–2590 (2007).
Kyle, R. A. et al. A long-term study of prognosis in…
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A second photoactivatable state of the anion-conducting channelrhodopsin GtACR1 empowers persistent activity
GtACR1 variant Q46E
To gain insights into the functional differences between CrChR2 and GtACR1, we compared the existing X-ray structures57,58 of the central constriction sites, which represent the functional cores of…
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