Bharate, S. B. & Lindsley, C. W. Call for papers: natural products driven medicinal chemistry. J. Med. Chem. 66, 16455–16456 (2023).
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Category: 5. Biology
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New-to-nature biocompatible chemistry for plastic waste upcycling
New-to-nature biocompatible chemistry for plastic waste upcycling
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Apical size reduction by macropinocytosis alleviates tissue crowding
Transgenic Xenopus and mRNA embryo injections
In vitro fertilizations were performed using standard protocols47,48,49,50 that have been approved by the Northwestern University Institutional Animal Care and Use Committee (IS00027128). Transgenic…
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Expanding the utility of precision oncology knowledge bases
Suehnholz, S. P. et al. Quantifying the expanding landscape of clinical actionability for patients with cancer. Cancer Discov. 14, 49–65 (2024).
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Yin,…
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Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma
Cell culture
The normal human melanocyte cell line PIG1 was provided by the Department of Ophthalmology, Peking University Third Hospital (Beijing, China). The UM cell lines 92.1 and MP46 and the human retinal pigment epithelial cell lines ARPE19…
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BRCA1 expression in ovarian cancer and its relationship with clinicopathological characteristics and prognosis
General data
Cancer tissue specimens, para-carcinoma tissue specimens and clinical data of 195 ovarian cancer patients diagnosed in our hospital from January 2016 to August 2021 were collected and analyzed. Among them, 101 cases were younger than…
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Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages
Li, X. et al. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct. Target. Ther. 8, 239 (2023).
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Wang, T….
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Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation
Toivanen, R. & Shen, M. M. Prostate organogenesis: tissue induction, hormonal regulation and cell type specification. Development 144, 1382–1398 (2017).
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Large-scale high-density brain-wide neural recording in nonhuman primates
Technology
The Neuropixels 1.0 NHP probe uses the same signal-conditioning circuits as the Neuropixels 1.0 probe1, integrating 384 low-noise readout channels with programmable gain and 10-bit resolution on a 130-nm Silicon-on-Insulator CMOS…
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Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function
In a recent study published in Nature, Chen et al.1 investigated the potential of RBPJ knock-out to improve stability and function of induced regulatory T cells (iTreg cells). This finding could…
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