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Category: 5. Biology
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Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity
Data collection
We used data on species morphological and geographical traits, threats and phylogenetic relationships to conduct this study. Trait data for 11,003 extant bird species66 were obtained from AVONET26. Under BirdLife taxonomy, only 8%…
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CD39 as a metabolic rheostat of immunoregulation
CD39 as a metabolic rheostat of immunoregulation
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Good neighbours transfer nucleotides | Nature Reviews Molecular Cell Biology
Tissue levels of deoxynucleotide triphosphates (dNTPs) are tightly regulated, and their dysregulation can impair DNA replication, leading to DNA damage and genetic instability. dNTPs can be synthesized de novo in a cell-autonomous pathway,…
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How to spy on condensates
Condensates can appear homogeneous in texture, but that misses the whole picture, as Ke Xu of the University of California, Berkeley and his team have found6. They experimented with droplets in vitro and developed a way to get FUS, an RNA-binding…
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Sleep prevents brain phosphoproteome disruption to safeguard survival
A Pr-SD sleep deprivation mouse model
A complete and long-lasting sleep deprivation method is of crucial importance for sleep studies. However, the attempt to prolong acute sleep deprivation by means of traditional approaches, such as gentle…
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Calopy — an advanced framework for the integration and analysis of indirect calorimetry data
Calopy — an advanced framework for the integration and analysis of indirect calorimetry data
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Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism
Apte, R. S. Age-related macular degeneration. N. Engl. J. Med 385, 539–547 (2021).
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Wong, W. L. et al. Global prevalence of age-related macular…
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A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1
Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271–275 (1999).
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PEX14 condensates recruit receptor and cargo pairs for peroxisomal protein import
De Duve, C. & Baudhuin, P. Peroxisomes (microbodies and related particles). Physiol. Rev. 46, 323–357 (1966).
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Poirier, Y., Antonenkov, V. D., Glumoff, T. &…
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