Ethical statement
All animal experiments were performed according to the protocols approved by the Animal Care Committee of the Interdisciplinary Research Center on Biology and Chemistry (IRCBC), Chinese Academy of Sciences (CAS) (Approval No….
Category: 5. Biology
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A multivalent mRNA vaccine elicits robust immune responses and confers protection in a murine model of monkeypox virus infection
MPXV mRNA vaccine design and fusion protein expression
In this study, we developed potent MPXV trivalent mRNA vaccines that target the antigens of both the IMV and EEV forms and characterized their physicochemical properties. First, we generated…
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Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation
Increased 3D ECM stiffness inhibits mammary epithelial cell differentiation
Both normal and transformed MECs undergo phenotypic changes in response to the mechanical stiffness of their microenvironment9,13,14. To understand how changes in…
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Chromosome-level genome assembly of Marco Polo Blister Beetle (Hycleus marcipoli)
Dossey, A. T. Insects and their chemical weaponry: new potential for drug discovery. Natural product reports 27, 1737–1757 (2010).
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Selander, R. B. Bionomics,…
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Worldwide genetic diversity of Plasmodium vivax Pv47 is consistent with natural selection by anopheline mosquitoes
Worldwide genetic diversity and population structure of Pv47
The genetic diversity of Pv47 (PVX_083240; PVP01_1208000.1) was established by analyzing 1199 Pv47 gene coding sequences (Supplementary Data 1) obtained in 28…
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In vivo anti-inflammatory evaluation of oxadiazole derivatives bearing flurbiprofen moiety using experimental and computational approaches
Chemistry
In the current study, we report flurbiprofen-based oxadiazole derivatives as potential anti-inflammatory agents. The combination of the oxadiazole nucleus, a recognized pharmacophore in medicinal/pharmaceutical chemistry, is considered…
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Phylogenetic and functional analysis of MYB genes unraveling its role involved in anthocyanin biosynthesis in H macrophylla
Peng, J. Q. Study on the regulation mechanism of pigment formation in sterile flowers of hydrangea. Dissertation. Central South University of Forestry and Technology. (2021). https://doi.org/10.27662/d.cnki.gznlc.2021.000858
Shi, C. C. & Mining…
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What 1,500-Year-Old Poo Reveals About Vanishing Species
Ancient kākāpō droppings have revealed a startling truth: more than 80% of the bird’s parasites have disappeared. This “coextinction” shows that as endangered animals struggle to survive, their microscopic companions often vanish first….
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Scientists Discover “Master Key” Protein for Stronger Memory and Learning
Research led by Rutgers suggests there could be significant new possibilities for treating neurodegenerative diseases and brain injuries. Researchers have uncovered how a specific protein supports the stability of connections between brain cells,…
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Squashing the spotted lanternfly problem may require enlisting other species
A beautiful menace is on the move in the United States. Polka-dotted, red-and-gray-winged insects are gliding along sidewalks, climbing on plants and crawling up buildings. Spotted youngsters are leaping away to avoid a sticky end at…
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