A trial of fetal cells for Parkinson’s disease brings lessons for the field
Category: 5. Biology
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A trial of fetal cells for Parkinson’s disease brings lessons for the field
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The role of genetic testing in small for gestational age infants
Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth…
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Exploring the role of infected keratinocytes during rabies virus infection
Hampson, K. et al. Estimating the global burden of endemic canine rabies. PLoS Negl. Trop. Dis. 9, e0003709 (2015).
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Wallace, R. M., Undurraga, E….
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GW: ultra-fast chromosome-scale visualization of genomics data
The HG002 human sample8, sequenced using Illumina (40× coverage), was downloaded from GIAB…
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When gut fibroblasts feed epithelial cells to death
Rodrigues Junior, J. I. et al. Pharmaceuticals 16, 1374 (2023).
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Dixon, S. J. et al. Cell 149, 1060–1072 (2012).
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Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins
In the version of the article initially published, in the Abstract, the text “enhanced green fluorescent protein-targeting” was incorrect; it has now been amended to “epidermal growth factor receptor-targeting”. In Figs. 3a, b, d, e and…
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Cytoplasmic anillin and Ect2 promote RhoA/myosin II-dependent confined migration and invasion
Mouse studies were approved by the Institutional Animal Care and Use Committee of The University of Texas, MD Anderson Cancer Center, which is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (IACUC…
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Lipid nanoparticle screening in nonhuman primates with minimal loss of life
mRNA synthesis
The template for in vitro transcription (IVT) of glycosylphosphatidylinositol-aVHH was purchased from Integrated DNA Technologies. The sequences (Supplementary Table 1) were codon-optimized for mouse (primary species) and human…
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Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R
Constructs
The full-length human PTH1R gene with its N-terminal signal sequence replaced with an HA signal sequence was subcloned into the pEG BacMam vector42, with a C-terminal eGFP–His8 tag and a 3C protease cleavage site. The FLAG epitope tag…
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Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency
This study revealed that a decrease in mtDNA copy number, which is crucial for the transition from OXPHOS-driven metabolism to aerobic glycolysis, is necessary for somatic cells to acquire and maintain pluripotency while undergoing stochastic…
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