Diet altered the gut microbial composition in mice
The study design are shown in Fig. 1. Prior to the transition from the basic maintenance (normal) diet, the dominant genera in the three groups of mice (normal, high-fat, and high-Fiber) were…
Category: 5. Biology
-
Efficacy and safety of anlotinib monotherapy for advanced hepatocellular carcinoma and clinical role of α-fetoprotein
Baseline clinical characteristics
Initially, a total of 210 patients with locally advanced or metastatic HCC were included in this study according to the inclusion and exclusion criteria (Table S1). Compared to anlotinib group, patients in…
Continue Reading
-
Molecular logic gates based on programmable self-assembly of DNA origami triangles for the detection of nucleic acid molecules
Detection of one type of nucleic acid molecules using a YES gate
The programmable detection of nucleic acids using edge-modified triangular DNA origami was demonstrated through structural assembly and logic-gated signal generation. As outlined in…
Continue Reading
-
Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy
Mitochondrial stress initiates the degradation of negative regulators of autophagy
The process of autophagy is critical for neuronal survival, yet neurons are largely resistant to major changes in basal autophagy flux. Recent progress has…
Continue Reading
-
Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis
SMURF1 and USP5 associate with the necrosome via RIPK3 during TNFα-induced necroptosis
To identify RIPK3-interacting proteins, we transfected HEK 293T cells with either FLAG-MOCK or FLAG-RIPK3 DNA constructs (Fig. 1A), followed by…
Continue Reading
-
Effects of different solvents on phytochemical constituents, in-vitro antimicrobial activity, and volatile components of Boehmeria rugulosa Wedd. wood extract
Phytochemical constituents of B. rugulosa wood
The efficiency of phytochemical extraction is influenced by several factors, including the chemical nature of the target compounds, extraction method, particle size, solvent polarity, and potential…
Continue Reading
-
Lipidomic signatures in Octopus vulgaris arm muscle reveal geographic variation along the Iberian Atlantic Coast
Pita, C. et al. Fisheries for common octopus in Europe: socioeconomic importance and management. Fish. Res. 235, 105820 (2021).
WoRMS Editorial Board. World Register of Marine Species.
Continue Reading
-
Multi-omics analysis of bariatric surgery’s impact on type 2 diabetes and prediabetes
The outcomes of bariatric surgery: clinical measurements, proteomics and metabolomics measures
The clinical and demographic characteristics of the patients at baseline (pre-surgery) and at 3, 6, and 9 months post-bariatric surgery were presented…
Continue Reading
-
Application of causal forest double machine learning (DML) approach to assess tuberculosis preventive therapy’s impact on ART adherence
Data source and study population
This research employed the University of Gondar Comprehensive and Specialized Hospital, Ethiopia’s electronic medical record system (EMR-ART). Routine secondary data on PLHIV-initiated ART at the hospital between…
Continue Reading
-
Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers
Protein expression and purification
The monomeric construct of the designed transmembrane (TM) homodimer TMHC262 studied in this work contains SpyTag and SnoopTag sequences at its N-terminus79,80, linked by GGSGGS linkers (Supplementary Fig. 1)….
Continue Reading