Category: 5. Biology

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  • Intraspecies warfare restricts strain coexistence in human skin microbiomes

    Intraspecies warfare restricts strain coexistence in human skin microbiomes

  • Garud, N. R., Good, B. H., Hallatschek, O. & Pollard, K. S. Evolutionary dynamics of bacteria in the gut microbiome within and across hosts. PLoS Biol. 17, e3000102 (2019).

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  • Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids

    Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids

  • World Health Organization. 2022 Mpox (Monkeypox) Outbreak: Global Trends. Vol. 2023 (World Health Organization, 2022).

  • World Health Organization. Monkeypox – United Kingdom of Great Britain and Northern Ireland. Vol. 2023 (World Health…

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  • Mechanism of RNA primer removal in plastid DNA replication

    Mechanism of RNA primer removal in plastid DNA replication

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Huang, X. et al. PEN1 catalyses RNA primer removal during plastid DNA replication in…

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  • Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

    Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

  • Hayes, J. D., Dinkova-Kostova, A. T. & Tew, K. D. Oxidative stress in cancer. Cancer Cell 38, 167–197 (2020).

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  • Principe, D. R. et al….

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  • Cell cycle regulation has shaped replication origins in budding yeast

    Cell cycle regulation has shaped replication origins in budding yeast

    Strains

    All primers, plasmids and strains used for strain construction are listed in Supplementary Tables 1, 2 and 3, respectively. The YJL3239 strain was a gift from J. Li29. The ARS317, ARS1, ARS1Δ and synthetic 90 bp origins were inserted in…

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  • Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms

    Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms

    U1 mutations in 762 mature B-cell neoplasm whole genomes

    We first re-analyzed the WGS data of 762 patients with B-cell neoplasms, 399 CLL and 163 mature B-cell lymphomas, to characterize the distribution of mutations along the U1 gene. We…

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  • High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes

    High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes

    Parasite culture

    Blood-stage 3D7 or NF54 P. falciparum parasites were cultured as previously described21. Briefly, parasites were cultured in human RBCs supplemented with 10% v/v Albumax I (Thermo Fisher, 11020), hypoxanthine (0.1 mM final…

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  • Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis

    Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis

    Systemic inflammation rewires aged MuSC epigenetic identity

    Muscle regeneration by MuSCs is modulated by both cell-intrinsic and cell-extrinsic mechanisms21,22,23. In the present study, we aimed to determine how age-related changes in the…

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