Whether regulatory T (Treg) cells are continuously dependent on FOXP3 is unclear. In Science Immunology, Jäger et al. use a genetically modified mouse model (Foxp3AID mice) that enables chemically induced degradation (55–95%) of FOXP3 protein…
Category: 5. Biology
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Cell wall stress in bacteria increases a nucleotide second messenger to reduce turgor
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This is a summary of: Brogan, A. P. et al. Cyclic-di-AMP modulates cellular turgor in response to defects in…
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An openEHR based infection control system to support monitoring of nosocomial bacterial clusters and contacts
In this work, we present SmICS as a digital supporting tool for infection control tasks such as monitoring of bacteria, contact networks and epidemiological analysis. Nosocomial outbreaks caused by different bacterial and viral pathogens, e.g.,…
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Mechanisms for licensing origins of DNA replication in eukaryotic cells
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Matsuoka, Y. Evolution of polyploid triticum wheats under cultivation:…
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Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation
STYK1 deletion alleviates pancreatic cancer progression
Interrogation of the GEPIA2 transcriptomic database revealed that STYK1 is overexpressed in several types of human cancers, especially pancreatic cancer (Supplementary Fig. 1a)….
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Absence of gut microbiota restoration following meropenem treatment in a systemic infection model
MacKinnon, M. C. et al. Mortality in Escherichia coli bloodstream infections: a multinational population-based cohort study. BMC Infect. Dis. 21, 606 (2021).
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Structure and mechanism of an actin-dependent bacterial phosphoryl AMPylase
Maculins, T., Fiskin, E., Bhogaraju, S. & Dikic, I. Bacteria–host relationship: ubiquitin ligases as weapons of invasion. Cell Res. 26, 499–510 (2016).
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A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity
Ethical Statement
All animal studies were approved under the Swiss license # 35726 (National No.) and #3196 (Basel Cantonal No.).
Cell lines and culturing
The human Griptite HEK293-Cas9 line was obtained from Thermo Fisher. GNE293 line was obtained…
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A systematic review of antimicrobial resistance transmission inferences at the human-livestock interface in Africa
Klümper, U. et al. Selection for antimicrobial resistance is reduced when embedded in a natural microbial community. ISME J.13, 2927–2937 (2019).
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