Sample collection
The location of 43 samples in this research (Table 1; Fig. 2A) completely overlapped with the natural distribution (Fig. 2B) of I. difengpi.
Generally, a large sample size would enhance the confidence in the results. However,…
Category: 5. Biology
-
Hinokiflavone is a novel CK2 inhibitor promoting apoptosis and synergizing with chemotherapeutic agents in cisplatin resistant bladder cancer cells
Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229–263. https://doi.org/10.3322/caac.21834 (2024).
…
Continue Reading
-
Genetic prediction of immune cells, inflammatory proteins, and metabolite-mediated association between gut microbiota and COPD: a Mendelian randomization study
In this genetically-based causal study, we identified several common microbial taxa associated with COPD risk. Specifically, we observed that CAG-475, CAG-485 sp002404675, Lactobacillus B ruminis, and UBA1191 were positively correlated with an…
Continue Reading
-
Novel kinetic and developmental transcriptomic pan-stress responses by embryonic stem cells
Four weak and two strong stressors were identified
It was previously established that control RA is like hyperosmotic sorbitol stress in the induction of extra-embryonic endoderm (XEN) using Pdgfra-promoter-GFP extra-embryonic endoderm (XEN, 1st…
Continue Reading
-
Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study
Hypertrophic scars are a common problem following skin injuries and healing beyond standard parameters. Such scars often exhibit an excessive proliferation of connective tissue40. Recent research has illuminated a significant interaction between…
Continue Reading
-
Yeast-derived glycolipids disrupt Candida biofilm and inhibit expression of genes in cell adhesion
Rokas, A. Evolution of the human pathogenic lifestyle in fungi. Nat. Microbiol. 7, 607–619. https://doi.org/10.1038/s41564-022-01112-0 (2022).
Google Scholar
…Continue Reading
-
Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing
Acquisition of CAFs
From the GSE131907 dataset, we obtained 88,144 scRNA-seq data from normal lung and LUAD tissues for subsequent analysis. After processing the data for quality control, the top 2000 differentially expressed genes (DEGs) obtained…
Continue Reading
-
Harnessing lateral gene transfer and endosymbiosis for adaptation
Most arthropods harbour a variety of endosymbionts that shape the life-history of their hosts. The recognition that organisms are comprised of entities from different taxa has challenged how we view organismal evolution. Although we know that…
Continue Reading
-
DDTC-Cu(I) inhibits human osteosarcoma cells growth by repressing MET/PI3K/AKT signaling pathway
Cell culture
The human OS cell lines (SaOS2, MG63, and U2OS) were acquired from ATCC and propagated at 37 °C in Dulbecco’s modified Eagle’s medium (DMEM) augmented with antibiotics and fetal bovine serum (FBS, 10%) in 5% CO2 humidified…
Continue Reading
-
Identifying artificial intelligence-generated content using the DistilBERT transformer and NLP techniques
This section examines the results of the proposed methodology based on ML and DL algorithms with feature engineering techniques to distinguish the content. These findings highlight the capabilities and challenges of models based on textual…
Continue Reading