Category: 5. Biology

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the nucleus but also integrates two…

Diet altered the gut microbial composition in mice

The study design are shown in Fig. 1. Prior to the transition from the basic maintenance (normal) diet, the dominant genera in the three groups of mice (normal, high-fat, and high-Fiber) were…

Baseline clinical characteristics

Initially, a total of 210 patients with locally advanced or metastatic HCC were included in this study according to the inclusion and exclusion criteria (Table S1). Compared to anlotinib group, patients in…

Detection of one type of nucleic acid molecules using a YES gate

The programmable detection of nucleic acids using edge-modified triangular DNA origami was demonstrated through structural assembly and logic-gated signal generation. As outlined in…

Mitochondrial stress initiates the degradation of negative regulators of autophagy

The process of autophagy is critical for neuronal survival, yet neurons are largely resistant to major changes in basal autophagy flux. Recent progress has…

SMURF1 and USP5 associate with the necrosome via RIPK3 during TNFα-induced necroptosis

To identify RIPK3-interacting proteins, we transfected HEK 293T cells with either FLAG-MOCK or FLAG-RIPK3 DNA constructs (Fig. 1A), followed by…

Phytochemical constituents of B. rugulosa wood

The efficiency of phytochemical extraction is influenced by several factors, including the chemical nature of the target compounds, extraction method, particle size, solvent polarity, and potential…