Category: 5. Biology

Animal use

Young female mice (6–10 weeks of age): C57BL/6J (CD45.2/H-2Kb, JAX#000664), B6.SJL-PtprcaPepcb/BoyJ (CD45.1, JAX# 002014), and B6(C)-Gt (ROSA)26Sor^{em1.1(CAG−cas9*−EGFP) Rsky/J} (Rosa26^Cas9 KI, JAX#028555) mice were purchased from…

Plant material and growth conditions

Tomato (Solanum lycopersicum cv. UC82B) and N. benthamiana plants were cultivated in growth cabinets at 26 °C, with 16 h photoperiod, 100 µmol m⁻² s⁻¹ light intensity and 75% relative humidity….

Virtual screening

We initiated our study by retrieving the two-fold symmetric Aβ₄₀ fibril structure 2LMN⁴⁵ from the PDB database. The 2LMN structure was originally derived from in vitro incubation of Aβ₄₀ under buffered conditions, followed by…

Theory

Grand canonical nonequilibrium candidate Monte Carlo

Ligand-based grand canonical nonequilibrium candidate Monte Carlo (GCNCMC) builds on the work of Samways et al. and Melling et al.^{59,63,82,83,84} The final result is presented here with a…

PSMA-targeted theranostic strategies, including PSMA-PET imaging and 177Lu-PSMA-617 radioligand therapy, have significantly revolutionized the clinical management of PCa. However, a subset of patients derived limited benefit from these…

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