In this study, images including axial brain slices and T1-weighted structural MRI data were used to diagnose Alzheimer’s disease. EfficientNetB2, InceptionV3, Regnetx006 and the proposed new models were employed on 224 × 224 rescaled MRI…
Category: 5. Biology
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Generalized linear modeling of flow cytometry data to analyze immune responses in tuberculosis vaccine research
Geneva: World Health Organization. Global Tuberculosis Report 2023. (ed World Health Organization). https://iris.who.int/ (World Health Organization, 2023).
Choi, Y. H. et al. Safety and immunogenicity of the ID93 + GLA-SE tuberculosis vaccine in…
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F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
A list of reagents and antibodies can be found in Supplementary Data 1.
Animals
This project was approved by the local ethical committee CEEA26 and the French government under the number APAFIS#25086-2020032312267714. Mical1fl/fl mice were kindly…
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Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods
Csicsák, D. et al. The effect of the particle size reduction on the biorelevant solubility and dissolution of poorly soluble drugs with different acid-base character. Pharmaceutics 15(1), 278 (2023).
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Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation
Ethics statements
This study has been approved by the Faculty of Science, Mahidol University Animal Care and Use Committee SCMU-ACUC Review (Protocol number: MUSC67-006-711), and all experiments were conducted in accordance with relevant…
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Self-splicing RNA circularization facilitated by intact group I and II introns
PIE can begin with the second step of the transesterification process
Group I introns, which are self-splicing ribozymes, enable RNA splicing without protein assistance, functioning through a two-step transesterification reaction that requires…
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Scientists just uncovered three ancient worlds frozen beneath Illinois for 300 million years
More than 300 million years ago, during the Carboniferous Period, much of northern Illinois outside Chicago — including what is now the Mazon Creek (“muh-ZAHN”) fossil site — was alive with ancient creatures thriving in lush, tropical swamps,…
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A 16-million-year-old amber fossil just revealed the smallest predator ant ever found
Wherever there’s dirt there’s bound to be ants, but one particular group is so adept at blending in with the ground that they hold the name “dirt ant” (Basiceros) all to themselves.
Now, an ancient fossil has revealed these elusive ants have seen…
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New insights into how MYOD controls muscle repair and regeneration
For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells. Similar to the instant kung fu education Keanu Reeves…
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All-atom models reveal novel protein misfolding mechanism
New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding. Proteins must fold into precise…
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