Recurrent LSCC characteristics and microbial community composition
We characterized the microbial communities of formalin-fixed paraffin-embedded (FFPE) tissue samples from 123 patients with LSCC in the LSCC cohort. Overall, a total of 180 LSCC…
Category: 5. Biology
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Improving early detection of Alzheimer’s disease through MRI slice selection and deep learning techniques
In this study, images including axial brain slices and T1-weighted structural MRI data were used to diagnose Alzheimer’s disease. EfficientNetB2, InceptionV3, Regnetx006 and the proposed new models were employed on 224 × 224 rescaled MRI…
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Generalized linear modeling of flow cytometry data to analyze immune responses in tuberculosis vaccine research
Geneva: World Health Organization. Global Tuberculosis Report 2023. (ed World Health Organization). https://iris.who.int/ (World Health Organization, 2023).
Choi, Y. H. et al. Safety and immunogenicity of the ID93 + GLA-SE tuberculosis vaccine in…
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F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
A list of reagents and antibodies can be found in Supplementary Data 1.
Animals
This project was approved by the local ethical committee CEEA26 and the French government under the number APAFIS#25086-2020032312267714. Mical1fl/fl mice were kindly…
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Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods
Csicsák, D. et al. The effect of the particle size reduction on the biorelevant solubility and dissolution of poorly soluble drugs with different acid-base character. Pharmaceutics 15(1), 278 (2023).
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Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation
Ethics statements
This study has been approved by the Faculty of Science, Mahidol University Animal Care and Use Committee SCMU-ACUC Review (Protocol number: MUSC67-006-711), and all experiments were conducted in accordance with relevant…
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Self-splicing RNA circularization facilitated by intact group I and II introns
PIE can begin with the second step of the transesterification process
Group I introns, which are self-splicing ribozymes, enable RNA splicing without protein assistance, functioning through a two-step transesterification reaction that requires…
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Contrasting niche dynamics in the invasion processes of two congeneric dinoflagellates
Soberón, J. & Nakamura, M. Niches and distributional areas: concepts, methods, and assumptions. Proc. Natl. Acad. Sci. USA. 106, 19644–19650 (2009).
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Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke
DiSabato, D. J., Quan, N. & Godbout, J. P. Neuroinflammation: the devil is in the details. J. Neurochem 139, 136–153 (2016).
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Gauberti, M. et al….
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Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47
CD47 mRNA 3′ UTR length affects its protein localization
Previous studies have demonstrated that global alterations in mRNA polyadenylation, resulting from the utilization of different PASs, play a crucial role in post-transcriptional gene…
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