In this study, we identified several key factors associated with the risk of developing postoperative upper limb lymphedema (PULL) in breast cancer patients. Our findings revealed that older age, higher BMI, advanced TNM stage, hypertension, and…
Category: 5. Biology
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Author Correction: Sarbecovirus RBD indels and specific residues dictating multi-species ACE2 adaptiveness
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or…
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Replay and representation dynamics in the hippocampus of freely flying bats
Cognitive functions for navigation and memory rely on emergent properties of neural ensembles in the hippocampus, such as activity replay1–5 and theta sequences6–9. Yet, whether and how these phenomena generalize across species with distinct…
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A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth
Cell lines
The cell lines of HEK293T, MDA-MB-468, Hs578T and MCF7 were cultured in DMEM Medium (Gibco, Cat: C11995500BT) with 10% Fetal bovine serum (FBS, ExCell, Cat: FSD500). The cell lines of HCC1806 and HCC1937 were cultured in RPMI 1640…
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Integrated bioinformatics and experimental analysis of mitochondrial-associated membrane function and mechanism in acute respiratory distress syndrome
Differentially expressed genes related to ARDS
By comparing ARDS samples with control groups, a total of 3152 differentially expressed genes (DEGs) were identified, showing significant differences between the two groups (corrected p < 0.05,…
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Quantifying the intra- and inter-species community interactions in microbiomes by dynamic covariance mapping
Dynamic covariance mapping (DCM)
Theory
We first provide a formal introduction to the ecological and mathematical theory behind DCM and its biological intuition. Without loss of generality, the microbiome as an ecological community can be described…
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First detection of Sindbis virus in wild birds in Nigeria
Ethical considerations
The experimental protocol was approved by the scientific committee of A.P. Leventis Ornithological Research Institute, University of Jos, and the work was carried out in accordance with institutional guidelines and national…
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Single-cell RNA sequencing dataset of hearts from wild type and Cyp26b1 knockout mouse embryos
Figure 1 provides an overview of the experimental design (Fig. 1a), and the raw data were processed via the bioinformatics workflow (Fig. 1b). The Cyp26b1 heterozygous mice (Cyp26b1+/−) model were generated using CRISPR/Cas9-mediated…
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Agonistic immune checkpoint regulator may harm the heart
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Jimenez, J. et al. The immune checkpoint regulator CD40 potentiates myocardial…
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Eliciting antitumor immunity via therapeutic cancer vaccines
Bagchi S, Yuan R, Engleman EG. Immune checkpoint inhibitors for the treatment of cancer: clinical impact and mechanisms of response and resistance. Annu Rev Pathol: Mechanisms Dis. 2021;16:223–49.
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