General synthetic procedure for compounds 3a-3h (5a-5h)
4-chloro-6,7-di(ethoxymethoxy)quinazoline (Compound 1, 0.1 mmol) was dissolved in 25 ml of isopropanol, followed by the addition of 3-aminophenylacetylene (0.11 mmol). The reaction mixture…
Category: 5. Biology
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Streptomyces maremycinicus sp. nov. and its secondary metabolite-biosynthetic gene clusters
Baltz RH. Gifted microbes for genome mining and natural product discovery. J Ind Microbiol Biotechnol. 2017;44:573–88.
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Berdy J. Bioactive microbial metabolites. J Antibiot….
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The evolutionary foundations of transcriptional regulation in animals
Brunet, T. & King, N. The origin of animal multicellularity and cell differentiation. Dev. Cell 43, 124–140 (2017).
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King, N. The unicellular…
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Experience-based risk taking is primarily shaped by prior learning rather than by decision-making
Participants
Consent to participate in this study was obtained in accordance with the Declaration of Helsinki and with approval from the Institutional Ethics Committee of the Hebrew University of Jerusalem. Two groups of 50 human participants each…
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Griseolutein T from Streptomyces seoulensis, newly identified via combined-culture with Tsukamurella pulmonis, as an efficacious therapeutic agent against multidrug-resistant bacteria
General
Actinomycetes and T. pulmonis were cultured using ISP2 and A3M media. ISP2 agar medium contained glucose (0.4%), malt extract (1.0%, Difco, BD Biosciences, CA, USA), yeast extract (0.4%, Bacto, BD Biosciences), and agar (1.5%) in distilled…
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Prediction and characterisation of the human B cell response to a heterologous two-dose Ebola vaccine
Henao-Restrepo, A. M. et al. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial. Lancet 386, 857–866 (2015).
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Intracranial directed connectivity links subregions of the prefrontal cortex to major depression
WHO. Depression and Other Common Mental Disorders: Global Health Estimates (World Health Organization (WHO) No. WHO/MS, 2017).
Lyus, R., Buamah, C., Pollock, A. M., Cosgrove, L. & Brhlikova, P. Global burden of disease 2017 estimates for major…
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Valproate independently activates Snf1, inhibits TORC1, and induces repression of INO1 transcription by increasing nuclear localization of Opi1
Czech, M. P. Dynamics of phosphoinositides in membrane retrieval and insertion. Annu. Rev. Physiol. 65, 791–815. https://doi.org/10.1146/annurev.physiol.65.092101.142522 (2003).
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Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure
Ethics statement
The IMPACT clinical trial was approved by the Office of Human Research Ethics (OHRE), University of North Carolina, Chapel Hill on April 9, 2013. The parent study titled, “IMPACT: Oral Immunotherapy (OIT) for Induction of…
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Application of digital twins for personalized oncology
National Academies of Sciences, Engineering, and Medicine. Foundational research gaps and future directions for digital twins. https://doi.org/10.17226/26894 (National Academies Press, 2024).
Leslie, M. “Digital twins” may improve treatment…
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