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Category: 5. Biology

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  • Benchmarking single-cell multi-modal data integrations

    Benchmarking single-cell multi-modal data integrations

  • Method of the Year 2019: single-cell multimodal omics. Nat.Methods 17, 1 (2020).

  • Baysoy, A., Bai, Z., Satija, R. & Fan, R. The technological landscape and applications of single-cell multi-omics. Nat. Rev. Mol. Cell Biol. 24, 695–713 (2023).

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  • Bat organoids at bat | Nature Methods

    Bat organoids at bat | Nature Methods

    Penninger and his laboratory focused on the Egyptian fruit bat Rousettus aegyptiacus, which is a reservoir for Marburg virus. Access to primary bat tissue is limited, and therefore the researchers first established a cryopreservation protocol for…

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  • Local microglial activation induced and labeled in the retina in a novel subretinal hemorrhage mouse model

    Local microglial activation induced and labeled in the retina in a novel subretinal hemorrhage mouse model

  • London, A., Benhar, I. & Schwartz, M. The retina as a window to the brain—from eye research to CNS disorders. Nature Reviews Neurology 2012 9:1 [Internet]. 2012 Nov 20 [cited 2024 Sep 18];9(1):44–53. Available from:

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  • TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway

    TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway

    Data acquisition

    Using the keywords ‘intervertebral disc degeneration (IDD)’, ‘degenerative disease’, and ‘nucleus pulposus tissue’, a search was conducted on the NCBI Gene database (https://www.ncbi.nlm.nih.gov/geo/). The scRNA-seq…

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  • Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation

    Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation

    Intersecting targets of GE and RA

    Based on draft guidelines for evaluating network pharmacology methods, using the 2D structural formula of GE as illustrated in Fig. 2A, a network pharmacology prediction of GE was conducted. Potential targets for…

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  • Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy

    Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy

    Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy

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  • Deep learning on routine full-breast mammograms enhances lymph node metastasis prediction in early breast cancer

    Deep learning on routine full-breast mammograms enhances lymph node metastasis prediction in early breast cancer

  • Ferlay, J. et al. Cancer statistics for the year 2020: an overview. Int. J. Cancer 149, 778–789 (2021).

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  • Dillekås, H., Rogers, M. S. & Straume, O. Are 90% of deaths from cancer…

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  • Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza vaccine with bacterial cell membrane-derived adjuvants

    Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza vaccine with bacterial cell membrane-derived adjuvants

  • Chen, Y.-Q. et al. Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies. Cell 173, 417–429.e10 (2018).

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  • Elevated neutrophil-to-lymphocyte ratios correlate with increased clozapine concentration-to-dose ratios during titration

    Elevated neutrophil-to-lymphocyte ratios correlate with increased clozapine concentration-to-dose ratios during titration

    The present study’s main finding was identifying a positive correlation between NLR and C/D ratio during clozapine titration. Although the relationship between inflammation and increased blood clozapine levels has been demonstrated in numerous…

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