Category: 5. Biology

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  • F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

    F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

    A list of reagents and antibodies can be found in Supplementary Data 1.

    Animals

    This project was approved by the local ethical committee CEEA26 and the French government under the number APAFIS#25086-2020032312267714. Mical1fl/fl mice were kindly…

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  • Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods

    Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods

  • Csicsák, D. et al. The effect of the particle size reduction on the biorelevant solubility and dissolution of poorly soluble drugs with different acid-base character. Pharmaceutics 15(1), 278 (2023).

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  • Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation

    Afatinib amplifies cAMP-induced fluid secretion in a mouse mini-gut model via TMEM16A-mediated fluid secretion and secretory cell differentiation

    Ethics statements

    This study has been approved by the Faculty of Science, Mahidol University Animal Care and Use Committee SCMU-ACUC Review (Protocol number: MUSC67-006-711), and all experiments were conducted in accordance with relevant…

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  • Self-splicing RNA circularization facilitated by intact group I and II introns

    Self-splicing RNA circularization facilitated by intact group I and II introns

    PIE can begin with the second step of the transesterification process

    Group I introns, which are self-splicing ribozymes, enable RNA splicing without protein assistance, functioning through a two-step transesterification reaction that requires…

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  • Contrasting niche dynamics in the invasion processes of two congeneric dinoflagellates

    Contrasting niche dynamics in the invasion processes of two congeneric dinoflagellates

  • Soberón, J. & Nakamura, M. Niches and distributional areas: concepts, methods, and assumptions. Proc. Natl. Acad. Sci. USA. 106, 19644–19650 (2009).

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  • Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke

    Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke

  • DiSabato, D. J., Quan, N. & Godbout, J. P. Neuroinflammation: the devil is in the details. J. Neurochem 139, 136–153 (2016).

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  • Gauberti, M. et al….

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  • Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47

    Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47

    CD47 mRNA 3′ UTR length affects its protein localization

    Previous studies have demonstrated that global alterations in mRNA polyadenylation, resulting from the utilization of different PASs, play a crucial role in post-transcriptional gene…

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  • Diabetic retinopathy classification using a multi-attention residual refinement architecture

    Diabetic retinopathy classification using a multi-attention residual refinement architecture

    This section focuses on the method of the proposed model. We first introduced the class-specific residual attention module and then proposed a multi-attention mechanism to improve the ability of small object detection (lesions detection). Then,…

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  • Identification of the AKR gene family in sweet cherry and its response to different abiotic stresses

    Identification of the AKR gene family in sweet cherry and its response to different abiotic stresses

    Phylogenetic analysis of the cherry AKR family genes

    To explore the evolutionary relationships of PaAKR gene family, a phylogenetic tree of 60 genes from cherry and Arabidopsis was constructed using MEGA7.0, which was divided into 4 subfamilies…

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