Category: 5. Biology

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  • O-GlcNAcylation shapes macrophage tissue residency and alternative activation

    Alternative activation of macrophages is induced by type 2 cytokines, such as IL-4, typically during T helper 2 (TH2) cell responses to parasitic infection. IL-4 drives macrophage effector programmes and local proliferation. Previous studies…

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  • Author Correction: Alternate-day fasting ameliorates α-synuclein pathology and suppresses inflammation via the gut-brain axis in an MPTP-induced subacute mouse model of Parkinson’s disease

    Author Correction: Alternate-day fasting ameliorates α-synuclein pathology and suppresses inflammation via the gut-brain axis in an MPTP-induced subacute mouse model of Parkinson’s disease

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  • A single-cell transcriptomic dataset profiling traumatic brain injury and NeuroD1-based gene therapy in mice

  • Stocchetti, N. et al. Severe traumatic brain injury: targeted management in the intensive care unit. Lancet Neurol 16, 452–464, https://doi.org/10.1016/s1474-4422(17)30118-7 (2017).

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  • Simon, D….

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  • Development of a controlled ex vivo human skin platform for quantitative evaluation of age-related functional biomarkers following application of topical treatments

  • Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell Jun. 6 (6), 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039 (2013).

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  • Campisi, J….

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  • Correction: Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancer

    Correction: Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancer

    Correction: Folate metabolism-associated CYP26A1 is a clinico-immune target in colorectal cancer

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  • Engineered Lactobacillus reuteri for scavenging reactive oxygen species and modulating oral microflora in periodontitis therapy

    Engineered Lactobacillus reuteri for scavenging reactive oxygen species and modulating oral microflora in periodontitis therapy

    Materials and reagents

    Dopamine hydrochloride (DA), N-Hydroxysuccinimide (NHS), phenylboric acid (PA), hyaluronic acid (HA) and 1-(3-Dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDC) were sourced from Sigma-Aldrich (St. Louis, USA)….

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  • Integrative network toxicology and experimental evidence reveal mechanisms underlying diethyl phthalate-induced initiation and progression of endometrial cancer

  • Gu, B. et al. Variations in incidence and mortality rates of endometrial cancer at the global, regional, and national levels, 1990–2019. Gynecol. Oncol. 161(2), 573–580 (2021).

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  • Feng, J.,…

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  • Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness

  • Miller, D. et al. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. Cochrane Database Syst. Rev. 8, CD012317.

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  • Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair

    Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair

    Assembly and Characterization of the BiRDS

    The BiRDS was constructed through rational design of complementary DNA/RNA hybrid strands based on Watson-Crick base pairing principles. All oligonucleotides were custom-synthesized and HPLC purified…

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