Scientists have successfully grown over 400 different types of nerve cells from stem cells in the lab—a groundbreaking step toward replicating the complexity of the human brain. By systematically experimenting with combinations of morphogens…
Category: 5. Biology
-
Scientists Grow 400+ Brain Cell Types in a Dish – Could This Be the Key to Curing Alzheimer’s?
-
High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability
High mtDNAc drives a more OXPHOS-like metabolic state in AML
To better understand the role of mtDNAc in a hematological context, we compared the mtDNAc between healthy and leukemic samples. mtDNAc was analyzed in BM aspirates of 482 newly…
Continue Reading
-
Wounding induces multilayered barrier formation in mature leaves via phytohormone signalling and ATML1-mediated epidermal specification
Leon, J., Rojo, E. & Sanchez-Serrano, J. J. Wound signalling in plants. J. Exp. Bot. 52, 1–9 (2001).
Google Scholar
Mousavi, S. A., Chauvin, A., Pascaud, F., Kellenberger, S. &…
Continue Reading
-
Chromosome-level genome assembly of starry flounder (Platichthys stellatus)
Orcutt, H. G. Z. The life history of the starry flounder, Platichthys stellatus (Pallas). 61-64 (UC San Diego: Library– Scripps Digital Collection, 1950).
Takeda, Y. & Tanaka, M. Freshwater adaptation during larval, juvenile and immature periods…
Continue Reading
-
Bile acids in the crosshairs for hypoglycaemia after gastric bypass
Li, T. & Chiang, J. Y. L. Bile acid signaling in metabolic and inflammatory diseases and drug development. Pharmacol. Rev. 76, 1221–1253 (2024).
Google Scholar
Salehi, M.,…
Continue Reading
-
Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout
Ethical statement
All procedures with animals were performed in an AAALAC-approved facility and received ethical approval from the Institutional Animal Care and Use Committee of the Albert Einstein College of Medicine (protocol 00001050) and Duke…
Continue Reading
-
Will AI become our Co-PI?
While robotics could optimize research workflows as indefatigable staff, the path to AI becoming a collaborative principal investigator lies in enhanced hypothesis generation. LLMs excel at processing and identifying patterns in vast datasets…
Continue Reading
-
Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation
DV cell populations display differential Brillouin shift dynamics during gastrulation
Cells along the DV axis change their shape in different ways at gastrulation stage (stage 629; Supplementary Fig. 1a–c, Supplementary Videos 1 and 2). We…
Continue Reading
-
Atlas of amnion development during the first trimester of human pregnancy
Human amnion collection
Human amnion tissue samples were collected from healthy pregnant donors after obtaining informed consent and following institutional ethical guidelines. All procedures were approved by the MRC-Wellcome Trust Human…
Continue Reading
-
Stem and progenitor cell proliferation are independently regulated by cell type-specific cyclinD genes
Lateral line organs possess two populations of dividing cells with unique gene expression profiles
To uncover the mechanisms underlying hair cell regeneration, we set out to identify new regulators of this process. In zebrafish, the antibiotic…
Continue Reading