Annotation preprocessing
3’ based scRNA-seq protocols use oligo(dT)s to capture polyadenylated RNAs, which introduces a bias in the location of reads towards the 3’ end of the RNAs (Fig. S10). Thus, we truncated the annotated isoforms in the…
Category: 5. Biology
-
Organelle biology: emerging themes and future directions
Organelle biology: emerging themes and future directions
Continue Reading
-
IL-17-secreting γδ T-cell-driven Siglec-F+ neutrophils mediate lung pathology in emphysema
Mills KHG. IL-17 and IL-17-producing cells in protection versus pathology. Nat Rev Immunol. 2023;23:38–54.
Google Scholar
Hong J, Kang MH, Lee J, Cha MS, Bae YS, Kim HY, et al. γδ(+)…
Continue Reading
-
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI
Cell culture
Human FLSs were isolated from the synovial tissues (STs) of patients with RA who underwent synovectomy in our hospital. FLSs were also isolated from patients with osteoarthritis (OA) as the negative control. RA and OA were diagnosed…
Continue Reading
-
Privacy-preserving multicenter differential protein abundance analysis with FedProt
FedProt workflow
FedProt is based on the accurate variance estimation workflow of DEqMS33 for MS data and uses the hybrid approach of federated learning and additive secret sharing30 in a manner similar to Flimma27. Federated learning is a machine…
Continue Reading
-
Human and artificial visual systems share a computational principle for transforming binocular disparity into depth representation
Participants
Twenty-five participants [20 males and five females, 24.5 ± 4.37 (mean ± SD) years old] from Osaka University participated in the fMRI experiments. Three male participants were excluded from the data analysis: two did not…
Continue Reading
-
Partitioning how biodiversity brings stability
Partitioning how biodiversity brings stability
Continue Reading
-
Lestaurtinib’s antineoplastic activity converges on JAK/STAT signaling to inhibit treatment naïve and therapy resistant forms ovarian cancer
Drug screen identifies lestaurtinib as an inhibitor of therapy-sensitive and -resistant ovarian cancer cells
To identify novel inhibitors of ovarian cancer cell viability, we performed a drug screen using 1 µM concentrations of a panel of small…
Continue Reading
-
Parkinson’s paradox: alpha-synuclein’s selective strike on SNc dopamine neurons over VTA
Animals: DATIREScre and Ai95(RCL-GCaMP6f)-D knock-in mice were obtained from Jackson Laboratory (Stock number: 006660 (DATIREScre), 024105 (Ai95D), Bar Harbor, ME, USA). DAT:cre, DAT:cre-GCaMP6, and C57Bl/6 mice aged between 1.5 and 2 months and…
Continue Reading
-
Transitive prediction of small-molecule function through alignment of high-content screening resources
Kirkpatrick, P. & Ellis, C. Chemical space. Nature 432, 823–824 (2004).
Google Scholar
Reymond, J.-L. The chemical space project. Acc. Chem. Res. 48, 722–730 (2015).
Continue Reading