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Category: 5. Biology
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The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment
Olsen, J. V. et al. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. 3, ra3 (2010).
Leslie, S. N. & Nairn, A. C. cAMP…
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A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects
Finnerup, N. B. et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 14, 162–173 (2015).
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Deciphering DEL pocket patterns through contrastive learning
Ma, P. et al. Evolution of chemistry and selection technology for DNA-encoded library. Acta Pharm. Sin. B 14, 492–516 (2024).
Gironda-Martínez, A., Donckele, E. J., Samain, F. & Neri, D….
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Novel marker genes for simultaneous detection of Salmonella, EHEC O157:H7, and Cronobacter
Allard, M. W. et al. Genomics of food-borne pathogens for microbial food safety. Curr. Opin. Biotechnol. 49(2), 224–229. https://doi.org/10.1016/j.copbio.2017.11.002 (2018).
Deng, L. & Wang,…
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Supercoiled DNA recognition and cleavage control in topoisomerase VI
McKie, S. J., Neuman, K. C. & Maxwell, A. DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. BioEssays 43, 2000286 (2021).
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Lipid metabolism in homeostasis and disease
Petrenko, V., Sinturel, F., Riezman, H. & Dibner, C. Lipid metabolism around the body clocks. Prog. Lipid Res. 91, 101235 (2023).
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Brown, E. M., Clardy, J. &…
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A Sugar Made by Gut Bacteria Can Drive Neurodegeneration
Researchers have uncovered a novel connection between two neurodegenerative disorders. This research, which was published in Cell Reports, found that gut bacteria are linked to the neurodegeneration that…
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A Sugar Made by Gut Bacteria Can Drive Neurodegeneration
Researchers have uncovered a novel connection between two neurodegenerative disorders. This research, which was published in Cell Reports, found that gut bacteria are linked to the neurodegeneration that…
Continue Reading
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A Sugar Made by Gut Bacteria Can Drive Neurodegeneration
Researchers have uncovered a novel connection between two neurodegenerative disorders. This research, which was published in Cell Reports, found that gut bacteria are linked to the neurodegeneration that…
Continue Reading