Structure activity relationships (SAR)
Structurally, 14-3-3 binds ERα by recognizing phospho-T594, the penultimate residue on the C-terminus of ERα. This creates a large, open, solvent-exposed pocket that can accommodate a small molecule….
Category: 5. Biology
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Characterization of the depolarization contrast line in the outer retina using polarization-sensitive optical coherence tomography
Optical Coherence Tomography (OCT) is a widely used imaging technique that has become an essential tool in ophthalmology. OCT measures the time delay and intensity of backscattered light from different tissue layers based on the principles of…
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Time-restricted feeding modulates neuron-glial interactions and circadian rhythm in the spinal cord of male Wistar rats fed a high-fat diet
Eichwald T, Talbot S. Neuro-immunity controls obesity-induced pain. Front Hum Neurosci. 2020;14:181.
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Zdziarski LA, Wasser JG, Vincent HK. Chronic pain…
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Association of gut microbiota and immune gene expression with response to targeted therapy in BRAF mutated melanoma
Previous studies have linked increased alpha diversity and microbial richness in melanoma patients, particularly species from the Firmicutes phylum, with favourable ICI response and adverse effects occurrence7,17,18. In parallel, BRAF- or…
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The effect of exogenous glutathione on meropenem susceptibility in Klebsiella pneumoniae-carbapenemases (KPC)-producing bacteria
Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45:1151–61.
Arnold…
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The defensome of prokaryotes in aquifers
The vast reservoir of prokaryotic defensome in groundwater
We established a metagenomic groundwater prokaryotic defensome catalog (GPDC) (see Supplementary Figs. S1, S2 for an overview), encompassing 190,810 defense genes, 90,824 defense systems,…
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Is Intelligence Genetic? Scientists Discover Heritable Brain State That Powers Cognitive Flexibility
Brain dynamics and cognition share genetic roots. Criticality may guide future brain health research. A recent study published on June 24 in PNAS presents strong evidence that brain criticality—the delicate balance between neural excitation and…
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When wily sea lions and determined wildlife officials sparred in Seattle
Excerpted from A YEAR WITH THE SEALS: Unlocking the Secrets of the Sea’s Most…
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Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size
Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size
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Posterior cingulate cortex downregulation training using fMRI neurofeedback in adolescents with early life adversity exposure: a randomized, single-blind trial
Sacks V, Murphey D. The prevalence of adverse childhood experiences, nationally, by state, and by race or ethnicity. Child trends. 2018;20.
Short AK, Baram TZ. Early-life adversity and neurological disease: age-old questions and novel answers. Nat Rev…
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