Category: 5. Biology

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  • Association of gut microbiota and immune gene expression with response to targeted therapy in BRAF mutated melanoma

    Association of gut microbiota and immune gene expression with response to targeted therapy in BRAF mutated melanoma

    Previous studies have linked increased alpha diversity and microbial richness in melanoma patients, particularly species from the Firmicutes phylum, with favourable ICI response and adverse effects occurrence7,17,18. In parallel, BRAF- or…

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  • The effect of exogenous glutathione on meropenem susceptibility in Klebsiella pneumoniae-carbapenemases (KPC)-producing bacteria

    The effect of exogenous glutathione on meropenem susceptibility in Klebsiella pneumoniae-carbapenemases (KPC)-producing bacteria

  • Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45:1151–61.

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  • The defensome of prokaryotes in aquifers

    The defensome of prokaryotes in aquifers

    The vast reservoir of prokaryotic defensome in groundwater

    We established a metagenomic groundwater prokaryotic defensome catalog (GPDC) (see Supplementary Figs. S1, S2 for an overview), encompassing 190,810 defense genes, 90,824 defense systems,…

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  • The role of exosomes in immunopathology and potential therapeutic implications

    The role of exosomes in immunopathology and potential therapeutic implications

  • Meldolesi J. Exosomes and ectosomes in intercellular communication. Curr Biol. 2018;28:R435–r444.

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  • Welsh JA, Goberdhan D, O’driscoll L, Buzas EI, Blenkiron C, Bussolati B, et al….

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  • Long-term benefits of TUDCA supplement in ARSACS zebrafish model

    Long-term benefits of TUDCA supplement in ARSACS zebrafish model

  • Bouhlal, Y., Amouri, R., Euch-Fayeche, E., Hentati, F. & G. & Autosomal recessive spastic ataxia of Charlevoix–Saguenay: An overview. Parkinsonism Relat. Disord. 17, 418–422 (2011).

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  • APOE deficiency triggers anti-tumour activity of macrophages in liver cancer

    APOE deficiency triggers anti-tumour activity of macrophages in liver cancer

  • Bray F, Laversanne M, Sung H, Me JF, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2022.

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  • Predicting the potential distribution of Podophyllum hexandrum Royle in the Himalaya under CMIP6 climate projections

    Predicting the potential distribution of Podophyllum hexandrum Royle in the Himalaya under CMIP6 climate projections

  • Shilky et al. Climate change: A major challenge to biodiversity conservation, ecological services, and sustainable development. in The Palgrave Handbook of Socio-Ecological Resilience in the Face of Climate Change 577–592 (Springer Nature…

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  • Phase separated condensates of ATRX regulate neural progenitor identity

    Phase separated condensates of ATRX regulate neural progenitor identity

    Human iPSC (hiPSC) culture

    The human iPSC control lines (1210B2 and RPC771 (ReproCELL)) and the genome-edited derivative of RPC771 (ΔEx15) were maintained as previously described50,65. The cells were cultured under feeder-free conditions in…

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