Lateral line organs possess two populations of dividing cells with unique gene expression profiles
To uncover the mechanisms underlying hair cell regeneration, we set out to identify new regulators of this process. In zebrafish, the antibiotic…
Category: 5. Biology
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Effectiveness of single-pill combination olmesartan/amlodipine/hydrochlorothiazide therapy in patients with apparent resistant hypertension
Effectiveness of single-pill combination olmesartan/amlodipine/hydrochlorothiazide therapy in patients with apparent resistant hypertension
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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex
Structure activity relationships (SAR)
Structurally, 14-3-3 binds ERα by recognizing phospho-T594, the penultimate residue on the C-terminus of ERα. This creates a large, open, solvent-exposed pocket that can accommodate a small molecule….
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Characterization of the depolarization contrast line in the outer retina using polarization-sensitive optical coherence tomography
Optical Coherence Tomography (OCT) is a widely used imaging technique that has become an essential tool in ophthalmology. OCT measures the time delay and intensity of backscattered light from different tissue layers based on the principles of…
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Time-restricted feeding modulates neuron-glial interactions and circadian rhythm in the spinal cord of male Wistar rats fed a high-fat diet
Eichwald T, Talbot S. Neuro-immunity controls obesity-induced pain. Front Hum Neurosci. 2020;14:181.
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Zdziarski LA, Wasser JG, Vincent HK. Chronic pain…
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Association of gut microbiota and immune gene expression with response to targeted therapy in BRAF mutated melanoma
Previous studies have linked increased alpha diversity and microbial richness in melanoma patients, particularly species from the Firmicutes phylum, with favourable ICI response and adverse effects occurrence7,17,18. In parallel, BRAF- or…
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The effect of exogenous glutathione on meropenem susceptibility in Klebsiella pneumoniae-carbapenemases (KPC)-producing bacteria
Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45:1151–61.
Arnold…
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The defensome of prokaryotes in aquifers
The vast reservoir of prokaryotic defensome in groundwater
We established a metagenomic groundwater prokaryotic defensome catalog (GPDC) (see Supplementary Figs. S1, S2 for an overview), encompassing 190,810 defense genes, 90,824 defense systems,…
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The role of exosomes in immunopathology and potential therapeutic implications
Meldolesi J. Exosomes and ectosomes in intercellular communication. Curr Biol. 2018;28:R435–r444.
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Welsh JA, Goberdhan D, O’driscoll L, Buzas EI, Blenkiron C, Bussolati B, et al….
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Long-term benefits of TUDCA supplement in ARSACS zebrafish model
Bouhlal, Y., Amouri, R., Euch-Fayeche, E., Hentati, F. & G. & Autosomal recessive spastic ataxia of Charlevoix–Saguenay: An overview. Parkinsonism Relat. Disord. 17, 418–422 (2011).
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