Category: 5. Biology

Continue Reading

  • scGPT: end-to-end protocol for fine-tuned retinal cell type annotation

    scGPT: end-to-end protocol for fine-tuned retinal cell type annotation

  • Cui, H. et al. scGPT: toward building a foundation model for single-cell multi-omics using generative AI. Nat. Methods 21, 1470–1480 (2024).

    CAS 
    PubMed 

    Google Scholar 

  • Theodoris, C. V. et al….

  • Continue Reading

  • Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning

    Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning

    Establishment of ARGS model and regulation mechanism of BLCA angiogenesis

    Differentially expressed analysis identified 147 angiogenesis-related genes (98 downregulated, 49 upregulated). A heatmap subsequently visualized ARGS expression patterns…

    Continue Reading

  • Molecular and genomic insights into multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa causing burn wound infections in Bangladesh

    Molecular and genomic insights into multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa causing burn wound infections in Bangladesh

    Sample collection and isolate identification

    Out of the initial 110 samples, 91 were selected for detailed analysis following preliminary assessment. From these 91 samples, 91 bacterial strains (n = 91) were successfully isolated which were…

    Continue Reading

  • Upregulation of long non-coding RNA SNHG11 promotes apoptosis and its molecular mechanisms in human osteosarcoma U2OS cells

    Upregulation of long non-coding RNA SNHG11 promotes apoptosis and its molecular mechanisms in human osteosarcoma U2OS cells

    Cloning and plasmid construction

    lncRNA SNHG11 pcDNA3.1-3xFlag-C plasmids and negative control plasmids were purchased from Youbio Biotech (Changsha, China). Transcript information: NR_003239.1.

    Cell culture and transfections

    U2OS cells (CL-0236,…

    Continue Reading

  • New benzimidazole-triazole glycoconjugates as anti-cancer agents and EGFR inhibitors

    New benzimidazole-triazole glycoconjugates as anti-cancer agents and EGFR inhibitors

    Chemistry

    All apparatuses data used to elucidate the chemical structure of new compounds is attached in the supplementary file, The azido sugars were prepared as earlier reported57,58. Representative NMR charts are attached in the Supplementary…

    Continue Reading

  • Recruitment, rewiring and deep conservation in flowering plant gene regulation

    Recruitment, rewiring and deep conservation in flowering plant gene regulation

  • Weirauch, M. T. et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell 158, 1431–1443 (2014).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Baumgart,…

  • Continue Reading

  • Disinfection of medical devices with a steam machine that operates at atmospheric pressure and is suitable for home usage

    Disinfection of medical devices with a steam machine that operates at atmospheric pressure and is suitable for home usage

  • Rowan, N. J., Kremer, T. & McDonnell, G. A review of spaulding’s classification system for effective cleaning, disinfection and sterilization of reusable medical devices: viewed through a modern-day lens that will inform and enable future…

  • Continue Reading

  • Correction: Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity

    Correction: Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity

    Correction: Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity

    Continue Reading

  • A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics

    A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics

  • Lelli, K. M., Slattery, M. & Mann, R. S. Disentangling the many layers of eukaryotic transcriptional regulation. Annu. Rev. Genet. 46, 43–68 (2012).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Continue Reading