Category: 5. Biology

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  • Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates

    Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates

    Recently, we reported a screening approach that used pharmacological inhibition of neddylation to identify small molecules whose mechanism of cytotoxicity requires Cullin RING Ligase activity16. A limitation of this approach is that only the…

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  • Author Correction: Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

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  • In Silico tool for predicting, designing and scanning IL-2 inducing peptides

    In Silico tool for predicting, designing and scanning IL-2 inducing peptides

    Datasets

    Main dataset

    A total of 8596 experimentally validated IL-2 inducing and non-inducing peptides were extracted from the largest repository of the immune epitope database (IEDB), filtering for MHC binders from any host organism that was…

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  • ARC3 required for constriction | Nature Plants

    ARC3 required for constriction | Nature Plants

    Chloroplast division requires the formation of a stromal Z ring composed of two tubulin-like FtsZ homologues, FtsZ1 and FtsZ2. This ring is linked to the inner envelope membrane through ARC6 and further connected to the outer envelope membranes…

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  • Mitochondrial origins of the pressure to sleep

    Mitochondrial origins of the pressure to sleep

    Drosophila strains and culture

    Flies were grown on media of cornmeal (62.5 g l−1), inactive yeast powder (25 g l−1), agar (6.75 g l−1), molasses (37.5 ml l−1), propionic acid (4.2 ml l−1),…

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  • Self-assessment of quality of life in patients after suffering from aneurysmal subarachnoid hemorrhage, principal component analysis

    Self-assessment of quality of life in patients after suffering from aneurysmal subarachnoid hemorrhage, principal component analysis

    The study suggests after PCA analysis that coiling correlated with higher psychological and environmental QoL, whereas clipping was associated with better physical and social QoL. One possible explanation for these differences may lie in the…

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  • DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation

    DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation

    Upregulated DDX39B protein is correlated with metastasis and poor prognosis in NSCLC

    To clarify the clinical relevance of DDX39B in NSCLC, we first determined the protein expression of DDX39B via our tissue microarray, which contained 119 NSCLC…

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  • Comparison of necrotizing enterocolitis (NEC)-related apoptosis factors between preterm and full-term rats

    Comparison of necrotizing enterocolitis (NEC)-related apoptosis factors between preterm and full-term rats

  • Rich, B. S. & Dolgin, S. E. Necrotizing enterocolitis. Pediatr. Rev. 38, 552–559 (2017).

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  • Keefe, G., Jaksic, T. & Neu, J. Necrotizing enterocolitis and short bowel syndrome….

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  • Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

    Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

    Curated metabolic reconstruction from reference genomes

    The curated reconstruction encompassed a non-redundant reference set of 263 Bifidobacterium genomes from cultured isolates, including 19 genomes from Bangladeshi strains sequenced in this…

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