Lipid nanoparticles (LNPs) are tiny fat bubbles that are used to deliver medicines, genes, and RNA into cells. However, in some cases LNPs can cause harmful inflammation as a result of the process of RNA delivery. Now, two new…
Category: 5. Biology
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4,000-year-old sheep tooth sheds light on enigmatic Eurasian plague
Around 5,000 years ago, a mysterious form of plague spread throughout Eurasia, only to disappear 2,000 years later. Known only from ancient DNA, this enigmatic ‘LNBA plague’ lineage has left scientists puzzled about its likely…
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Researchers develop precise tool to identify omega positions in lipids
Omega-3 fatty acids are known to be an essential part of a healthy diet. As humans cannot produce them, they have to be consumed in sufficient amounts. However, omega-6, -7, -9, and -10 fatty acids also play important roles in the…
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AI model can design optimal drug candidates without any prior molecular data
Traditional drug development methods involve identifying a target protein (e.g., a cancer cell receptor) that causes disease, and then searching through countless molecular candidates (potential drugs) that could bind to that…
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Unsuspecting sea creature has Earth’s hardest teeth
The planetâs humble mollusks have teeth that mean business. Researchers are…
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New imaging technique reveals how antibodies reshape cancer cell receptors
A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.
Therapeutic antibodies have…
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ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC
Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J. & Der, C. J. Drugging the undruggable RAS: mission possible? Nat. Rev. Drug Discov. 13, 828â851 (2014).
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In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression
This pilot in vitro study explored how decompression-induced microbubble nucleation and acoustic softening contribute to flow instability and potential SFC in human blood. The experimental setup simulated pressure conditions relevant to DCS,…
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A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides
Azaldegui, C. A., Vecchiarelli, A. G. & Biteen, J. S. The emergence of phase separation as an organizing principle in bacteria. Biophys. J. 120, 1123â1138 (2021).
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Melting KRAS resistance | Nature Chemical Biology
Hofmann, M. H., Gerlach, D., Misale, S., Petronczki, M. & Kraut, N. Cancer Discov. 12, 924â937 (2022).
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Zhao, Z., Mei, Y., Wang, Z. & He, W. Cancers…
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