Category: 5. Biology

Mice

Ripk^1tm1.1Pvdb, B6.129(Cg)-Foxp3^{tm4(YFP/icre)Ayr}/J, Foxp3^{tm1(CD2/CD52)Shori}, and B6.129-Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/J mice have been previously described [56,57,58,59]. Ripk1^ΔFoxp3 mice and Ripk1^fl/fl Foxp3^Cre/wt mice were generated by…

This research complies with all relevant ethical regulations. Appropriate study approvals are included in the relevant sections below.

Zebrafish

Cloning

For the tfap2b-GFP reporter, two open areas of chromatin that were statistically enriched in…

Tibial loading metrics

Tibial bending moments

The experimental test was carried out for 54 immature oocytes. At first, each oocyte was individually injected into the channel with a very low flow rate of about 0.05 µl per minute. The flow was then increased stepwise at intervals of 10 s….

The segAB locus and genomic neighbour conservation

The segAB genes are found widely on chromosomes of Thermoproteota and Euryarchaeota. The 3’ end of segA overlaps with the 5’ end of segB in most genera, suggesting that the genes form a single…

Ethical approvals

The study was approved by national and local ethics review boards at each site, and was carried out to Good Clinical Practice (ICH GCP) standards. More specifically, at each recruitment center, namely (i) King’s College London…