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Category: 5. Biology
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Lactobacilli biology, applications and host interactions
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Crowther, T. W. et al. Scientists’ call…
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Structural variation in 1,019 diverse humans based on long-read sequencing
Samples and DNA extraction
We initially selected 1,064 samples from the 1kGP collection, sourcing genomic DNA from Coriell and discarding low-quality DNA. The study complied with all relevant regulations for work with human participants. DNA was…
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(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway
Animals
All mice were maintained on a C57/BL6 background, used in accordance with the guidelines of the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals. All mice were housed in temperature-controlled rooms…
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N-acetylaspartate from fat cells regulates postprandial body temperature
Animal studies
Animal procedures were approved by the Institutional Animal Care and Use Committee of Baylor College of Medicine (BCM). Experimental animals were housed at 23 °C in a barrier-specific pathogen-free animal facility with a 12-h…
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Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway
Structure determination of human LYCHOS
Human LYCHOS were expressed in Sf9 cells and purified through tandem affinity and size exclusion chromatography (SEC) in the absence or presence of cholesterol/CHS. Although all purified LYCHOS proteins,…
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The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice
Spermatogenesis is defective in Kdm2a-deficient mice
We sought to study the role of the H3K36me1/2 demethylase KDM2A7 in adult mammal biology. To this end, we targeted the Kdm2a locus in C57BL/6 J ESCs with a vector containing an IRES-β-geo…
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ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA
ILF3 is decreased in RSL3-mediated ferroptosis
To identify key RBPs involved in ferroptosis regulation in CRC, we constructed a ferroptosis cell model in SW620 cells by treating them with RSL3. Ferroptosis was confirmed by assessing Glutathione…
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Nipah virus vaccines evaluated in pigs as a ‘One Health’ approach to protect public health
Ethics statement
Animal studies were performed in accordance with the relevant national legislation (UK—Animals (Scientific Procedures) Act 1986, Australia—Australian Code for the Care and Use of Animals for Scientific Purposes (8th Edition),…
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