People need to sleep, and sleep deprivation can cause many changes in the brain. But we have a poor understanding of why sleep is so crucial. New research has examined a fruit fly model to assess how sleep…
Category: 5. Biology
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The sugar that sparked life: Why ribose was RNA’s first choice
In living organisms today, complex molecules like RNA and DNA are constructed with the help of enzymes. So how did these molecules form before life (and enzymes) existed? Why did some molecules end up as the building blocks of life and not…
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New insights reveal how FtsZ and ZapA cooperate during bacterial cell division
Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the most essential biological processes. Understanding the precise mechanism behind this dynamic process can…
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Genetic diversity analysis of four Parabramis pekinensis populations based on microsatellite markers
Gu, H., Feng, Y. & Yang, Z. Differential study of the Parabramis pekinensis intestinal microbiota according to different gonad development stages. Fish. Sci. 88, 721–731 (2022).
Xu, W. et al….
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Lactobacilli biology, applications and host interactions
Balloux, F. & van Dorp, L. Q&A: what are pathogens, and what have they done to and for us? BMC Biol. 15, 91 (2017).
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Crowther, T. W. et al. Scientists’ call…
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Structural variation in 1,019 diverse humans based on long-read sequencing
Samples and DNA extraction
We initially selected 1,064 samples from the 1kGP collection, sourcing genomic DNA from Coriell and discarding low-quality DNA. The study complied with all relevant regulations for work with human participants. DNA was…
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(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway
Animals
All mice were maintained on a C57/BL6 background, used in accordance with the guidelines of the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals. All mice were housed in temperature-controlled rooms…
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N-acetylaspartate from fat cells regulates postprandial body temperature
Animal studies
Animal procedures were approved by the Institutional Animal Care and Use Committee of Baylor College of Medicine (BCM). Experimental animals were housed at 23 °C in a barrier-specific pathogen-free animal facility with a 12-h…
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Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway
Structure determination of human LYCHOS
Human LYCHOS were expressed in Sf9 cells and purified through tandem affinity and size exclusion chromatography (SEC) in the absence or presence of cholesterol/CHS. Although all purified LYCHOS proteins,…
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