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This is a summary of: Mrdjen, D. et al. Spatial proteomics reveals Alzheimer’s disease-specific human…
Category: 5. Biology
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Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration
Human tissue harvest and preparation
All donors were patients in the School of Stomatology, The Fourth Military Medical University, and have signed informed consent to this study. Experimental procedures of human samples were approved by the…
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PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation
Plasmids
PEAK1 constructs were generated by cloning human PEAK1 cDNA into the pTriEx-FC, pTriEx-GFP, and pTriEx-3×Flag vectors, respectively. Mouse PEAK1 was generated by inserting mouse Peak1 cDNA into the pTriEx-GFP vector. The lentiviral…
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Proteomic mechanism of sugar and organic acid metabolism during Korla fragrant pear (Pyrus sinkiangensis Yü) fruit development
Sato, Y. et al. Collaborative research project on conservation of fruit tree genetic resources in Xinjiang Uygur autonomous district of China. In Annual Report on Exploration and Sintroduction of Plant Genetic Resources, vol. 24 137–151…
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New method genetically blocks mosquitoes from transmitting malaria
Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.
Recent efforts to…
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Dinosaurs roamed in multi-species herds, fossilized footprints show
In Africa, wildebeest and zebra roam the plains in multi-species herds. The…
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Climate change may be pushing fungal allergy season earlier
There’s no rest for allergy sufferers.
Fungal allergy season gets going an average of 22 days earlier than it did 20 years ago, researchers report in the July GeoHealth. Rising temperatures and altered precipitation are linked to…
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Skin wrinkles because it stretches like Silly Putty
Everybody’s skin wrinkles with age, but the actual science behind why it…
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New collaborative effort harnesses AI to drive ALS drug discovery in Louisiana
Answer ALS is proud to announce the launch of a groundbreaking collaborative initiative aimed at accelerating AI-powered drug discovery for ALS and other neurodegenerative diseases. This effort, known as the Louisiana AI Drug…
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Cancer cells go up in flames—thanks to this deep-sea sugar
Promoting pyroptosis — an inflammatory form of programmed cell death — has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain sugar molecule, or exopolysaccharide,…
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