Category: 5. Biology

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  • Structural and functional insights of ZnT1 C-terminal domain as a regulator of zinc transport

    Structural and functional insights of ZnT1 C-terminal domain as a regulator of zinc transport

    Plasmids

    The human ZnT1 CTD codon-optimized sequence was incorporated into the pET28a plasmid, with a His‐tag at the N‐terminus (pET28CTD). This construct contains only the structural part of the CTD (residues 345‐425). The complete rat ZnT1…

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  • Equivariant learning leveraging geometric invariances in 3D molecular conformers for accurate prediction of quantum chemical properties

    Equivariant learning leveraging geometric invariances in 3D molecular conformers for accurate prediction of quantum chemical properties

    Datasets

    In this study, we primarily utilize the QM9 dataset to train and evaluate our proposed 3DMSE framework. The QM9 dataset contains 134,000 small organic molecules with up to 9 heavy atoms (C, O, N, and F), each associated with a set of…

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  • Deubiquitinase USP6 stabilizes oncogenic RUNX1 fusion proteins to promote the leukemic potential and malignant progression

    Deubiquitinase USP6 stabilizes oncogenic RUNX1 fusion proteins to promote the leukemic potential and malignant progression

  • Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

    PubMed 

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  • Biocompatible Lossen rearrangement | Nature Catalysis

    Biocompatible Lossen rearrangement | Nature Catalysis

    Now, Stephen Wallace and colleagues report this chemistry in the presence of microbial cells and interface it with plastic degradation and microbial metabolism to synthesize valuable compounds from waste. The researchers started their…

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  • Author Correction: Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide

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  • Finding the lock to fit the key: Ebola virus entry

    How does a virus enter a host cell? This is often one of the first questions researchers try to answer when a new virus emerges, owing to how critical viral entry is for infection to occur. Viruses cannot replicate on their own and must hijack…

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  • Correction: Bioengineered tumor microenvironments with naked mole rats high-molecular-weight hyaluronan induces apoptosis in breast cancer cells

    Correction: Bioengineered tumor microenvironments with naked mole rats high-molecular-weight hyaluronan induces apoptosis in breast cancer cells

  • School of Life Science and Technology, Harbin Institute of Technology, Harbin, China

    Yufang Zhao, Shupei Qiao, Xiaolu Hou, Hui Tian, Shuai Deng, Kangruo Ye & Weiming Tian

  • Research Center of Basic Space Science, Space Environment Stimulation…

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  • Isolation and identification of bacteriophage against Escherichia coli ATCC 25922 and their biofilm Inhibition studies

    Isolation and identification of bacteriophage against Escherichia coli ATCC 25922 and their biofilm Inhibition studies

    Bacterial strain

    The collected ATCC E. coli strain was used as the host for phage isolation. Crystal violet assay revealed that E. coli strain formed strong biofilms. Spectroscopic analysis showed OD values of 0.5 and 0.8 at 24 and 48 h,…

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  • Chromosome level de Novo hybrid assembly of Asian honeybee, Apis cerana Koreana

    Chromosome level de Novo hybrid assembly of Asian honeybee, Apis cerana Koreana

    Genome assembly statistics

    After adapter trimming, 19.58 Giga base pairs were obtained in 4,527,921 Nanopore reads (Table 1). The average read length was 4,324 bp, and the read coverage was 87.78X. (Table 1; Supplementary Table S2; Supplementary…

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