Vaccination is one of the most effective ways to protect populations from viral infections. A popular method for vaccine development involves attenuating viruses to weaken their ability to cause disease for use as live vaccines. Live attenuated…
Category: 5. Biology
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Diagnostic yield of trio exome sequencing as a first-tier test for identifying genetic causes of pregnancy loss
Heaney S, Tomlinson M, Aventin A. Termination of pregnancy for fetal anomaly: a systematic review of the healthcare experiences and needs of parents. BMC Pregnancy Childbirth. 2022;22:441.
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Single-cell RNA sequencing analysis revealed the immunosuppressive remodeling of tumor-associated macrophages mediated by the MIF-CD74 axis in gastric cancer
Single-cell atlas of non-malignant and malignant gastric tissues
To fully characterize the single-cell profile of gastric malignancies, a total of 14 samples were collected, including 11 patients with primary tumor (GC) gastric cancer and 3…
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Metabolic reprogramming and prognostic insights in molecular landscapes driven by glycolysis in ovarian cancer
Characterizing GRGs in OC progression dynamics
A total of 457 GRGs were identified as significantly differentially expressed when comparing the transcriptomes of ovarian cancer samples from the TCGA-OC dataset with those of normal ovarian tissues…
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Honoring Daniel Aberdam’s scientific and human legacy
Daniel Aberdam, a distinguished scientist and cherished friend, passed away on April 7th 2025. Daniel Aberdam was not only a brilliant researcher but also an inspiration to his generation—admired equally for his scientific achievements and for…
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Single-cell image-based screens identify host regulators of Ebola virus infection dynamics
Hoenen, T., Groseth, A. & Feldmann, H. Therapeutic strategies to target the Ebola virus life cycle. Nat. Rev. Microbiol. 17, 593–606 (2019).
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Hoenen, T. et al. Inclusion…
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In silico and in vitro investigations reveal pan-PPAR agonist activity and anti-NAFLD efficacy of polydatin by modulating hepatic lipid-energy metabolism
Dixon, E. D., Nardo, A. D., Claudel, T. & Trauner, M. The role of lipid sensing nuclear receptors (PPARs and LXR) and metabolic lipases in obesity, diabetes and NAFLD. Genes (Basel). 12, 645 (2021).
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Arrest Peptide Profiling resolves co-translational folding pathways and chaperone interactions in vivo
Ratiometric fluorescence measurements report on co-translational folding in live cells
The 17 amino acid AP from the SecM protein arrests translation elongation by forming specific interactions with the polypeptide exit tunnel inside the ribosome
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Mathematics on the blackboard! Emotional processing of math-related pictures in individuals with math anxiety
Ashcraft, M. H. & Moore, A. M. Mathematics anxiety and the affective drop in performance. J. Psychoeduc. Assess. 27, 197–205 (2009).
Barroso, C. et al. A meta-analysis of the relation between…
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Structural and functional insights of ZnT1 C-terminal domain as a regulator of zinc transport
Plasmids
The human ZnT1 CTD codon-optimized sequence was incorporated into the pET28a plasmid, with a His‐tag at the N‐terminus (pET28CTD). This construct contains only the structural part of the CTD (residues 345‐425). The complete rat ZnT1…
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