This study investigated the phytochemical composition of Persea americana (avocado) leaves using FT-IR and GC-MS, focusing on the influence of two solvents, ethanol and ethyl acetate, on extractable bioactive compounds. While the ethanolic…
Category: 5. Biology
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A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function
Identifying eukaryotic RBPs
To identify RBPs across 690 eukaryotic organisms, we scanned protein sequences for well-characterized RBDs using HMMER57 with recommended parameter settings (‘full sequence E value’ (sequence_eval) ≤ 0.01 and…
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Motion sickness susceptibility modulates the impact of electrical vestibular stimulation on postural control
Golding, J. F. Motion sickness. Handb. Clin. Neurol. 137, 371–390 (2016).
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Cha, Y. H. et al. Motion sickness diagnostic criteria: consensus document of the…
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U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays
The PTRE-seq MPRA library features multiple unexpected size heterogeneities
As part of an effort to understand position-dependent ARE regulation, we repeated the PTRE-seq experiment24 with slight modifications. HeLa cells were transfected with the…
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Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases
Staunton, J. & Wilkinson, B. Biosynthesis of erythromycin and rapamycin. Chem. Rev. 97, 2611–2629 (1997).
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Floss, H. G. & Yu, T. W. Rifamycin – mode of action,…
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Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows
Leebens-Mack, J. H. et al. One thousand plant transcriptomes and the phylogenomics of green plants. Nature 574, 679–685 (2019).
Jiao, Y. et al. Phylogenomic analysis reveals ancient genome…
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MDM4 overexpression alleviates developmental and hematopoietic defects in Fancg deficient mice
Ceccaldi R, Sarangi P, D’Andrea AD. The Fanconi anaemia pathway: new players and new functions. Nat Rev Mol Cell Biol. 2016;17:337–49.
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Garaycoechea JI, Crossan GP,…
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Citrus reticulata (mandarin) | Nature Ecology & Evolution
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Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases
Single-cell multiome dataset
Single-cell multiome (snRNA-seq + snATAC-seq) data of the human left ventricle and lung were processed and clustered on the basis of RNA modality using Scanpy137. The cells with high-quality RNA information (total…
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Scientists open new atlas of genetic diversity with advanced sequencing
A landmark study harnesses long-read sequencing to reveal vast, previously undetected structural variations in human DNA, reshaping our understanding of genetics and disease potential.
Study: Structural variation in 1,019…
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