Establishment of the ZZW-115 resistant cells
To model the emergence of therapeutic resistance in a manner that more closely reflects clinical tumor evolution, we chose to generate ZZW-115-resistant cells through a population-based adaptive…
Category: 5. Biology
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Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis
Cell culture and bacterial culture
CT26 cell line was provided by the Department of Pathology of Nanfang Hospital with STR profiling and cultured in Dulbecco’s Modified Eagle’s Medium (DMEM, Gibco, Grand Island, NY, USA) supplemented with 10%…
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Association between vitamin D receptor FokI gene polymorphism and risk of type 2 diabetes mellitus in the Ethiopian population
Othman, G. O., Aali, M. H., Saeed, C. H. & Najeeb, H. A. Vitamin D receptor gene ApaI and TaqI polymorphism in patients with type II diabetes mellitus using Pcr-Rflp method in Kurdistan region. 17(1) (2023).
Mohammed, A. A. et al. Allelic…
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Evidential deep learning-based drug-target interaction prediction
Datasets
Three datasets DrugBank68, Davis59, and KIBA60 were used for model evaluation. Supplementary Table 1 summarizes these datasets.
DrugBank: the data used in this study were published on January 3, 2020 (version 5.1.5). Drugs with inorganic…
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Inoculation with Talaromyces trachyspermus and arbuscular mycorrhizal fungus alongside sulfonylurea herbicides alters Orobanche aegyptiaca and tomato growth
The mycorrhizal colonization rate was found to be significantly influenced by fungi and herbicides (P ≤ 0.01). However, the application methods of the herbicides were not effective in the greenhouse experiment. In plants that were not…
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Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome
Boyle, J. A. & Teede, H. J. PCOS: refining diagnostic features in PCOS to optimize health outcomes. Nat. Reviews Endocrinol. 12 (11), 630–631 (2016).
Li, J. et al. Effect of exposure to…
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A complex between IF2 and NusA suggests early coupling of transcription-translation
Labeling of IFs and fMet-tRNAfMet
To fluorescence label the IFs for live-cell single-molecule tracking, we explored if the addition of a HaloTag compromises IF activity in supporting cell growth (Supplementary Note 1)….
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Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts
Whole blood transcriptomics
Two participants provided three blood samples each (Fig. 1A). The blood samples were collected at the pre-flight mark (T0, within two weeks before departure), at post-flight (T2, within 24 hours after landing), and at…
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Removal of E. coli O157:H7 coliform bacteria from sewage wastewater using silver doped borate bioglass
Preparation of BAgX BG samples
Five types of silver-doped borate BG samples, BAg0, BAg1, BAg2, BAg3, and BAg4, were prepared by the melt-quenching method at high temperatures between 1100 and 1200 °C as spherical-shaped discs (Fig. 2). After the…
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A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate
Ethical statement
All procedures were performed in compliance with relevant laws and institutional guidelines. Animal studies were approved by the Second Hospital of Shandong University Ethics Committees (Approval No. KYLL-2022A128). Human…
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