Subject
Two original germ-free strains BALB/cAnSlac (BC) and Kunming (KM) were bred in Shanghai Tenth People’s Hospital, Tenth People’s Hospital of TongJi University in Shanghai, China. The SPF NOD/SCID Il2rg–/– (NSG) strain was purchased…
Category: 5. Biology
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Somites are a source of nephron progenitors in zebrafish
snGESTALT analysis suggests a developmental relationship between muscle and kidney
Consistent with the prior observation in Sandkhol Carp, we found that zebrafish NPCs, which are fluorescently labelled in the Tg(lhx1a:EGFP) transgenic line7,16,…
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Genetic subtype-guided immunochemotherapy in relapsed and refractory diffuse large B cell lymphoma: a phase 2 investigator-initiated nonrandomized clinical trial (GUIDANCE-06)
Study design and participants
This phase 2 single-arm, open-label trial (ClinicalTrials.gov NCT05348213) adopted a prospective cohort design. Enrollment was restricted to R/R DLBCL patients. Participant inclusion criteria included: age 18–75…
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Impacts of temperature on recombination rate and meiotic success in thermotolerant and cold-tolerant yeast species
Aggarwal DD, Rybnikov S, Cohen I, Frenkel Z, Rashkovetsky E, Michalak P, Korol AB (2019) Desiccation-induced changes in recombination rate and crossover interference in Drosophila melanogaster: evidence for fitness-dependent plasticity. Genetica…
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HPLC based identification of phenolics and biological activities in Elaphomyces mushroom extracts
Singh, D. et al. In Silico molecular screening of bioactive natural compounds of Rosemary essential oil and extracts for Pharmacological potentials against rhinoviruses. Sci. Rep. 14, 17426 (2024).
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The Lpp-OmpA-BtaE fusion protein causes a protective immune response against Brucella melitensis in mice
In this study, the enhanced immunogenic response and protective efficacy of the BtaE antigen against B. melitensishas been demonstrated in a murine model through its incorporation into the Lpp-OmpA-BtaE construct. The integration of computational…
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Benchmarking large language models for replication of guideline-based PGx recommendations
Coleman JJ, Pontefract SK. Adverse drug reactions. Clin Med. 2016;16:481–5.
Slight SP, Seger DL, Franz C, Wong A, Bates DW. The national cost of adverse drug events resulting from inappropriate…
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PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding
Chaffer CL, Weinberg RA. How does multistep tumorigenesis really proceed?. Cancer Discov. 2015;5:22–24.
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
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Chromosome-level genome assembly of Sinocyclocheilus jii based on PacBio HiFi and Hi-C sequencing
Sampling and genome survey
A healthy female S. jii weighing 23 g was collected from Fuchuan Yao Autonomous County, Guangxi, China (Fig. 1). After anesthesia with fish anesthetic MS-222, the specimen was immediately dissected. Muscle, heart,…
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Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer’s disease by repressing FoxO1 gene expression
Escape latency time trials
Line graph in Fig. 2a shows means of escape latency time (Second) at different time points. The related data are shown in Table 1. There was a significant interaction effect between group and time on escape latency…
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