In this study, the enhanced immunogenic response and protective efficacy of the BtaE antigen against B. melitensishas been demonstrated in a murine model through its incorporation into the Lpp-OmpA-BtaE construct. The integration of computational…
Category: 5. Biology
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Benchmarking large language models for replication of guideline-based PGx recommendations
Coleman JJ, Pontefract SK. Adverse drug reactions. Clin Med. 2016;16:481–5.
Slight SP, Seger DL, Franz C, Wong A, Bates DW. The national cost of adverse drug events resulting from inappropriate…
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PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding
Chaffer CL, Weinberg RA. How does multistep tumorigenesis really proceed?. Cancer Discov. 2015;5:22–24.
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
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Chromosome-level genome assembly of Sinocyclocheilus jii based on PacBio HiFi and Hi-C sequencing
Sampling and genome survey
A healthy female S. jii weighing 23 g was collected from Fuchuan Yao Autonomous County, Guangxi, China (Fig. 1). After anesthesia with fish anesthetic MS-222, the specimen was immediately dissected. Muscle, heart,…
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Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer’s disease by repressing FoxO1 gene expression
Escape latency time trials
Line graph in Fig. 2a shows means of escape latency time (Second) at different time points. The related data are shown in Table 1. There was a significant interaction effect between group and time on escape latency…
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A 20-feature radiomic signature of triple-negative breast cancer identifies patients at high risk of death
Almansour, N. M. Triple-negative breast cancer: a brief review about epidemiology, risk factors, signaling pathways, treatment and role of artificial intelligence. Front. Mol. Biosci. 9, 836417 (2022).
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In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol
A total of 22 microbial cultures were used in the initial screening of (-)-α-bisabolol (1). Five biotransformation metabolites (2–6) were produced by Cordyceps sinensis ATCC 24400 (2 and 6), Alternaria alternata ATCC 10801 (3) and Aspergillus…
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Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures
Melbournevirus encodes a conserved shorter H2B-H2A doublet variant that is likely essential for viral fitness
We suspected that the mel_149 gene product might be a virally encoded H2B-H2A variant, as it has been shown to be associated with viral…
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Longitudinal dynamics of clinical and neurophysiological changes in parkinson’s disease over four and a half years
Moustafa, A. A. et al. Motor symptoms in parkinson’s disease: A unified framework. Neurosci. Biobehav Rev. 68, 727–740. https://doi.org/10.1016/j.neubiorev.2016.07.010 (2016).
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Biosynthesis of selenium nanoparticles from Dahlia pinnata tuberous roots with antibacterial, antidiabetic, and erythrocyte membrane protective activities
Materials
Plant Materials: Fresh D. pinnata L. roots were collected from Orman Botanical Garden, Giza. Plant collection was conducted in compliance with local and international regulations. Permission for collecting Dahlia pinnata L. was obtained…
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