Category: 5. Biology

KRAS was historically regarded as an “undruggable” target until the development of KRAS^G12C allele-specific inhibitors. The discovery of the switch II pocket within the KRAS protein has rapidly accelerated the development of KRAS^G12C…

High cell content of reactive oxygen species (ROS) could result in oxidative stress, and antioxidants prevent their formation and inhibit their activity². Certain antioxidants could have beneficial effects on colorectal cancer initiation and…

Conditional ablation of mural cells in zebrafish larvae

To clarify the roles of pericytes in regulating angiogenesis during wound healing, we generated a transgenic zebrafish line that enables the conditional ablation of mural cells by employing…

Tumor and control group differential expression analysis and GSEA enrichment analysis

Through comparing tumor and control groups, 751 DEGs were identified, showing a statistically significant difference between the two groups (|(log2FC)| >1.5, P…

In this section, we describe the data simulation process, the methods tested for the four key analytical questions, and the evaluation metrics used to assess their performance.

Simulation setups

Microbiome and metabolome data were simulated using…

Study population

We conducted a single-center, retrospective cohort study of VLBW infants admitted to the Medical University of South Carolina (MUSC) Neonatal Intensive Care Unit (NICU) between January 1, 2018, to December 31, 2021, and evaluated…