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Category: 5. Biology

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  • Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory

    Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory

  • Ranganath, C. Binding items and contexts: The cognitive neuroscience of episodic memory. Curr. Directions Psychological Sci. 19, 131–137 (2010).

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  • Yim, H., Dennis, S. J. & Sloutsky, V. M. The…

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  • An enzyme for high-yield, ATP-driven C-terminal thioester generation

    An enzyme for high-yield, ATP-driven C-terminal thioester generation

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Frazier, C. L. et al. Engineered reactivity of a bacterial E1-like enzyme enables…

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  • Aberrant protein translation promotes T cell exhaustion

    Aberrant protein translation promotes T cell exhaustion

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Liu, Y. et al. LARP4-mediated hypertranslation drives T cell dysfunction in tumors….

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  • Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning

    Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning

    This research does not involve human participants, animal subjects, or the use of biological samples requiring institutional ethics approval. All relevant ethical regulations were followed.

    Overview of cpDistiller

    cpDistiller consists of three main…

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  • Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis

    Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis

    Patients

    Paraffin-embedded samples of 50 primary DLBCL patients and 30 reactive hyperplasia patients in Shandong Provincial Hospital between 2014 and 2019 were collected. Samples of reactive hyperplasia were used as controls. Peripheral blood,…

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  • Structural basis for mTORC1 regulation by the CASTOR1–GATOR2 complex

    Structural basis for mTORC1 regulation by the CASTOR1–GATOR2 complex

    Cloning and protein purification

    GATOR2 purification

    Codon-optimized DNA encoding all five subunits of GATOR2 (MIOS, WDR59, WDR24, SEH1L and Sec13) was synthesized by Twist Biosciences and subcloned into the pCAG vector. The construct with MIOS was…

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  • Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state

    Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state

    Engineering patterned ECM substrates of defined area

    To create defined areas of ECM proteins, we used μCP to print arrays of circular collagen I patterns to which HeLa (Kyoto) cells can adhere via α1β1 and α2β1 integrins57 and circular…

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  • Inflammation sends old muscle stem cells into a rusty meltdown

    Inflammation sends old muscle stem cells into a rusty meltdown

    Inflammation sends old muscle stem cells into a rusty meltdown

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