TLR3-mediated TBK1 and IRF3 activation requires ANKIB1, an unrecognized component of the TLR3-SC, to promote type-I and type-III IFN induction
After confirming that HOIP and its linUb-generating activity were dispensable for TBK1 activation…
Category: 5. Biology
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Mapping epigenetic gene variant dynamics: comparative analysis of frequency, functional impact and trait associations in African and European populations
Toth, R. et al. Genetic variants in epigenetic pathways and risks of multiple cancers in the GAME-ON consortium. Cancer Epidemiol. Biomark. Prev. 26, 816–825 (2017).
Cebrian, A. et al….
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Transcriptional signatures associated with female receptivity and longevity in genetically male-sterile wheat (Triticum aestivum L.)
Erenstein, O. et al. Springer International Publishing,. in Wheat Improvement: Food Security in a Changing Climate (eds Matthew P. Reynolds & Hans-Joachim Braun) 47–66 (2022).
Gerber, J. S. et al. Global spatially explicit yield gap time trends…
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Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design
Catterall, W. A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26, 13–25 (2000).
Yu, F. H. & Catterall, W. A. Overview of…
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Distinguishing between response conflict and error expectancy in inhibitory error processing: the role of the presupplementary motor cortex
Fu, Z., Sajad, A., Errington, S. P., Schall, J. D. & Rutishauser, U. Neurophysiological mechanisms of error monitoring in human and non-human primates. Nat. Rev. Neurosci. 24, 153–172 (2023).
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The network pharmacology prediction and experiment validation of Astragalus membranaceus for alleviating silicosis fibrosis via decreasing MMP9 and EGFR expression
Leung, C. C., Yu, I. T. & Chen, W. Silicosis. Lancet 379, 2008–2018 (2012).
Jamshidi, P. et al. Silicosis and tuberculosis: A systematic review and meta-analysis. Pulmonology 31, 2416791…
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USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
Kratz, K. et al. Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents. Cell 142, 77–88 (2010).
MacKay, C. et al. Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage…
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Native alleles at lhcb6 shape photosynthetic efficiency and early growth in maize
McCouch, S. et al. Feeding the future. Nature 499, 23–24 (2013).
Swarup, S. et al. Genetic diversity is indispensable for plant breeding to improve crops. Crop Sci. 61, 839–852 (2021).
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Targeting AT1 receptors with telmisartan protects SH-SY5Y cells from 6-OHDA induced Parkinsonian neurotoxicity
Fahn, S. Description of parkinson’s disease as a clinical syndrome. Ann. N. Y. Acad. Sci. 991, 1–14. https://doi.org/10.1111/j.1749-6632.2003.tb07458.x (2003). 2003/07/09.
Magrinelli, F. et…
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Plant cell structure could hold key to cancer therapies and improved crops
Can the bend of a banana give us insight into cancer? What does the shape of a rice grain have to do with infertility? The proteins that give plants their shape and structure are also involved in human disease. A team led by researchers at the…
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