Category: 5. Biology

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  • U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays

    U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays

    The PTRE-seq MPRA library features multiple unexpected size heterogeneities

    As part of an effort to understand position-dependent ARE regulation, we repeated the PTRE-seq experiment24 with slight modifications. HeLa cells were transfected with the…

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  • Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases

    Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases

  • Staunton, J. & Wilkinson, B. Biosynthesis of erythromycin and rapamycin. Chem. Rev. 97, 2611–2629 (1997).

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  • Floss, H. G. & Yu, T. W. Rifamycin – mode of action,…

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  • Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows

    Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows

  • Leebens-Mack, J. H. et al. One thousand plant transcriptomes and the phylogenomics of green plants. Nature 574, 679–685 (2019).

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  • Jiao, Y. et al. Phylogenomic analysis reveals ancient genome…

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  • MDM4 overexpression alleviates developmental and hematopoietic defects in Fancg deficient mice

    MDM4 overexpression alleviates developmental and hematopoietic defects in Fancg deficient mice

  • Ceccaldi R, Sarangi P, D’Andrea AD. The Fanconi anaemia pathway: new players and new functions. Nat Rev Mol Cell Biol. 2016;17:337–49.

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  • Garaycoechea JI, Crossan GP,…

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