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Category: 5. Biology
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Spatial transcriptomics reveals macrophage domestication by epithelial cells promotes immunotherapy resistance in small cell lung cancer
Spatial single-cell atlas of SCLC patients with distinct treatment efficacies
Eighteen extensive SCLC patients who received a combination of immunothearpy with chemotherapy were enrolled. Among them, 8 patients had progressive disease (PD), and 10…
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Genome wide association studies in yam reveal the challenge of high heterozygosity
Genetic material and plant phenotyping
A comprehensive study was conducted using 173 genotypes of D. rotundata, comprising 86 elite breeding clones, 77 genebank accessions, and ten farmers’ varieties. The detailed information regarding these…
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Inhibition of anti-apoptotic Bcl-2 family members promotes synergistic cell death with ER stress inducers by disrupting autophagy in glioblastoma
Price M, Ballard C, Benedetti J, Neff C, Cioffi G, Waite KA, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2017-2021. Neuro Oncol. 2024;26:vi1–vi85.
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Physical and psychological optimization of tele-exercise programs by establishing guidelines
Glossary section—operative definitions
Experts agreed on the operative definitions from the literature and enriched them with further details. The experts agreed on the following statements: Tele-exercise, which originally started as a branch of…
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Genome-resolved long-read sequencing expands known microbial diversity across terrestrial habitats
Locey, K. J. & Lennon, J. T. Scaling laws predict global microbial diversity. Proc. Natl Acad. Sci. USA 113, 5970–5975 (2016).
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Lewis, W. H., Tahon,…
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Spatial map of microglial diversity beyond proteopathy
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Mrdjen, D. et al. Spatial proteomics reveals Alzheimer’s disease-specific human…
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Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration
Human tissue harvest and preparation
All donors were patients in the School of Stomatology, The Fourth Military Medical University, and have signed informed consent to this study. Experimental procedures of human samples were approved by the…
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PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation
Plasmids
PEAK1 constructs were generated by cloning human PEAK1 cDNA into the pTriEx-FC, pTriEx-GFP, and pTriEx-3×Flag vectors, respectively. Mouse PEAK1 was generated by inserting mouse Peak1 cDNA into the pTriEx-GFP vector. The lentiviral…
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