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Category: 5. Biology
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Pericyte-mediated regulation of angiogenesis during cutaneous wound healing in adult zebrafish
Conditional ablation of mural cells in zebrafish larvae
To clarify the roles of pericytes in regulating angiogenesis during wound healing, we generated a transgenic zebrafish line that enables the conditional ablation of mural cells by employing…
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The role of glucocorticoids in hepatocellular carcinoma through integrated bioinformatics analysis and experimental validation
Tumor and control group differential expression analysis and GSEA enrichment analysis
Through comparing tumor and control groups, 751 DEGs were identified, showing a statistically significant difference between the two groups (|(log2FC)| >1.5, P…
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A systematic benchmark of integrative strategies for microbiome-metabolome data
In this section, we describe the data simulation process, the methods tested for the four key analytical questions, and the evaluation metrics used to assess their performance.
Simulation setups
Microbiome and metabolome data were simulated using…
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Neonatal acute kidney injury and neurodevelopmental impairment: investigating associations in very low birthweight infants
Study population
We conducted a single-center, retrospective cohort study of VLBW infants admitted to the Medical University of South Carolina (MUSC) Neonatal Intensive Care Unit (NICU) between January 1, 2018, to December 31, 2021, and evaluated…
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Neighbourhood diversity increases tree growth in experimental forests more in wetter climates but not in wetter years
Griscom, B. W. et al. Natural climate solutions. Proc. Natl Acad. Sci. USA 114, 11645–11650 (2017).
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Loreau, M. et al. Biodiversity as insurance:…
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Survival benefit associated with first-line androgen receptor pathway inhibitors for de novo metastatic castration-sensitive prostate cancer
Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.
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Piombino C, Oltrecolli M, Tonni E, Pirola M, Matranga R, Baldessari C, et al. De novo…
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Biotin/sulfasalazine combination therapy alleviates acetic acid-induced ulcerative colitis in rats via modulation of S1PR1/NF-κB/IL-23/STAT3/COX-2 axis
Gisbert, J. P. & Chaparro, M. Clinical usefulness of proteomics in inflammatory bowel disease: A comprehensive review. J. Crohns Colitis 13(3), 374–384 (2019).
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Jackson, B. & De…
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Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing
Reagents
The following reagents were used: BAPTA-AM (196419), diphenyleneiodonium chloride (DPI) (300260), Calbiochem; phorbol 12-myristate 13-acetate (PMA) (P8139), thapsigargin (T9033), LPS E.coli (L2630), homovanillic acid (306-08-1),…
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Comparing the precision of two digital PCR applications for copy number comparisons in protists
Hutchins, D. A. & Fu, F. Microorganisms and ocean global change. Nat. Microbiol. 2, 1–11 (2017).
Tilman, D. et al. The influence of functional diversity and composition on ecosystem…
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